食管小细胞癌中Survivin、NF-κB、VEGF-C的表达及其与MVD、MLVD的相关性  

Expressions of Survivin,NF-κB,VEGF-C and Their Relationship with MVD,MLVD in Small Cell Carcinoma of Esophagus

作　　者：庞雅青[1] 马杰[2] 魏冰[2] 孙喜斌[3] 许林平[3] 买玲[3] 

机构地区：[1]郑州大学基础医学院,郑州450008 [2]河南省肿瘤医院病理科 [3]河南省肿瘤研究所

出　　处：《肿瘤防治研究》2010年第12期1383-1386,共4页Cancer Research on Prevention and Treatment

基　　金：河南省社会公益预研项目基金资助(341700700)

摘　　要：目的探讨食管小细胞癌中Survivin、NF-κB和VEGF-C的表达与MVD、MLVD之间的关系及其肿瘤生物学意义。方法采用免疫组织化学二步法检测34例食管小细胞癌中Survivin、NF-κB、VEGF-C的表达情况,并对微血管密度(MVD)和微淋巴管密度(MLVD)计数。结果 Survivin、NF-κB、VEGF-C在食管小细胞癌中的表达率分别为35.29%、67.65%和79.41%。Survivin、MLVD与食管小细胞癌淋巴结转移和浸润深度均无关。VEGF-C、NF-κB、MVD与淋巴结转移密切相关,与浸润深度无关。NF-κB、VEGF-C阳性病例的MVD明显高于阴性表达的病例。结论食管小细胞癌中VEGF-C、NF-κB、MVD均与淋巴结转移密切相关,在食管癌发生发展中起着重要作用,有可能成为临床生物治疗的参考指标。Objective To investigate the expression of Survivin,NF-κB,VEGF-C,MVD and MLVD,their relationships with the behaviors of the small cell carcinoma of the esophagus and with MVD and MLVD.Methods Envision immunohistochemical method was used to detect the expression of Survivin,NF-κB,VEGF-C and MVD,MLVD in 34 cases of the small cell carcinoma of the esophagus.Results Positive rates of survivin,NF-κB and VEGF-C positive rate was 35.29%,67.65% and 79.41%,respectively.There were no connection between the expression of Survivin,MLVD and the tumor＇s invasion depth and lymphatic metastasis.There was a significant correlation between the expression of VEGF-C,NF-κB,MVD and the tumor＇s lymphatic metastasis,but there were no relationship to the tumor＇s invasion depth.MVD in the positive expression of NF-κB was higher than those in the negative expressed cases.Conclusion There were significant correlations between VEGF-C,NF-κB,MVD and the tumor＇s lymphatic metastasis.Thus they may play an important role in the small cell carcinoma and may be a molecular biological basis to clinical therapy.

关 键 词：食管癌 SURVIVIN NF-ΚB VEGF-C 微血管密度 微淋巴管密度 

分 类 号：R735.1[医药卫生—肿瘤]