石杉碱甲胶囊及片剂治疗阿尔采末病(英文)  

Huperzine-A in capsules and tablets for treating patients with Alzheimer disease

作　　者：徐嗣荪 蔡正宜 瞿正万 杨任民[2] 蔡永亮[2] 王共强[2] 苏雪倩[3] 钟杏圣[3] 程瑞艳[3] 徐维安 李建新 冯斌 

机构地区：[1]上海浦东精神卫生中心,上海200112 [2]安徽中医学院神经病研究所,合肥230006 [3]杭州第七人民医院,杭州310013 [4]上海第三精神病院,中国201905 [5]浙江精神卫生研究所,杭州311122

出　　处：《中国药理学报》1999年第6期486-490,共5页Acta Pharmacologica Sinica

基　　金：Project supported by Zhejiang Health Bureau.

摘　　要：比较石杉碱甲胶囊和片剂对阿尔采末病的疗效和安全性．方法：采用双盲双模拟法将入选的６０例阿尔采末病人随机等分两组，胶囊组每次口服石杉碱甲胶囊４粒和安慰剂片４片；片剂组每次口服石杉碱甲片（哈伯因）４片和安慰剂胶囊４粒，两组均每日两次，６０日为一疗程．所有病人都测量ＷＭＳ，ＭＭＳ，ＨＤＳ－Ｒ，ＩＡＤＬ，ＧＢＳ痴呆综合征量表和各种检查以及氧自由基．结果：两组所有心理量表值疗后均有显著改善（Ｐ＜０．０１），而两组间无明显差异（Ｐ＞０．０５），且等效检验合格；两组的自由基病理变化疗后也明显减轻，但也无组间差异（Ｐ＞０．０５）；两组未发生严重不良反应．结论：石杉碱甲胶囊和片剂治疗阿尔采末病时疗效和安全性相等。AIM: To compare the efficacy and safety between huperzine-A (Hup) in capsules and tablets for beating patients with Alzheimer disease (AD). METHODS: Using multicenter, prospective, double-blind, doublemimic, parallel, positive controlled and randomized methods, 60 patients meeting with the NINCDS criteria of AD were divided into 2 equal groups. Patients in the capsule group received 4 capsules of Hup (each contains 50 μg) and 4 tablets of placebo (lactose and starch inside); while the tablet group received 4 tablets of Hup (each contains 50 μg) and 4 capsules of placebo, po, twice a day for 60 d. All the patients were evaluated with a lot of related ranting scales, and physiological and laboratory examination. RESULTS: There were significant differences (P<0.01) on all the psychological evaluations between 'before' and 'after' the 60-d trial of 2 groups, but there was no significant difference between 2 groups by group t test (P>0.05). The changes of oxygen free radicals in 2 groups showed marked approvement. No severe side effect besides moderate to mild nausea was found in both groups. CONCLUSION: There is equal efficacy and safety between Hup in capsule and tablet for treating patients with AD, and Hup can reduce the pathological changes of the oxygen free radicals in the plasma and erythrocytes of patients with AD.

关 键 词：石杉碱甲 治疗 阿尔采末病 胶囊 片剂 

分 类 号：R749.160.5[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]