红景天对含表柔比星方案化疗患者的血清肌钙蛋白Ⅰ、心肌背向散射积分及左室射血分数的影响  

Effect of Rhodiola on Serum Troponin 1,Cardiac Integral Backscatter and Left Ventricle Ejective Fraction of Patients Who Received Epirubicin-contained Chemotherapy

作　　者：沈伟生[1] 高春恒[2] 张华[3] 邓立春[1] 袁明[1] 张瑶[1] 奚蕾[1] 

机构地区：[1]东南大学医学院附属江阴医院肿瘤科,江苏214400 [2]东南大学医学院附属江阴医院超声科 [3]东南大学医学院附属江阴医院心内科

出　　处：《中国中西医结合杂志》2010年第12期1250-1252,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江苏省无锡市卫生系统07-08年度中医药科研资助项目(No.ZXM0806)

摘　　要：目的探讨红景天对应用表柔比星(EPI)后患者的心肌保护作用。方法应用EPI3个化疗周期后出现心肌受损的患者42例,随机分为中药红景天组(治疗组)和对照组,比较1个月后血清肌钙蛋白Ⅰ(cTnⅠ)、心肌背向散射积分(IBS)及左室射血分数(LVEF)的变化及症状改善情况。结果两组患者治疗后cTnⅠ分别为(0.54±0.05)mg/L、(0.98±0.03)mg/L,IBS分别为(55.23±5.72)%、(61.23±5.96)%;LVEF分别为(68±3)%、(57±2)%,两组比较,差异有统计学意义(P<0.05)。结论红景天可明显改善应用EPI后患者的心功能,抑制cTnI和IBS的升高。Objective To investigate the myocardial protective effect of Rhodiola on patients who received epidoxorubicin （EPI） treatment.Methods Forty-two patients with myocardial damage who received 3 courses of EPI contained chemotherapy were randomly and equally assigned to two groups,the Rhodiola treated group and the control group.After 1-month treatment,the changes in serum troponin Ⅰ （cTnⅠ） level,cardiac integral backscatter （IBS）,and left ventricle ejective fraction （LVEF） in patients were observed and compared between groups.Results Levels of cTnI in the treated group and control group were （0.54±0.05）mg/L and （0.98±0.03）mg/L respectively,IBS were 55.23±5.72 scores and 61.23±5.96 scores,and LVEF （%） were 68±3 and 57±2 respectively,all showed significant differences between groups （P0.05）.Conclusion Rhodiola can improve cardiac function,and suppress the increase of serum cTnⅠ level and IBS in patients who received EPI treatment.

关 键 词：红景天 表柔比星 肌钙蛋白Ⅰ 心肌背向散射积分 左室射血分数 

分 类 号：R730.5[医药卫生—肿瘤]