结肠癌患者低氧诱导因子1α和微血管密度的表达  

Expression and significance of HIF-1α and MVD in patients with colon cancer

作　　者：高潺潺[1] 成红艳[1] 顾晓怡[1] 刘申香[1] 

机构地区：[1]东南大学附属中大医院肿瘤科,南京市210009

出　　处：《江苏医药》2010年第23期2741-2743,共3页Jiangsu Medical Journal

摘　　要：目的探讨结肠癌患者低氧诱导因子1α(HIF-1α)的表达及其与结肠癌新生血管生成、结肠癌进展转移的关系。方法采用免疫组化方法,检测46例结肠癌患者组织标本和相应的癌旁正常黏膜组织中HIF-1α与CD34的表达,并与结肠癌的临床病理特征结合分析。结果微血管密度(MVD)染色密度在结肠癌组织中明显高于结肠癌癌旁组织;有淋巴结转移、Dukes分期为C、D期者,CD34与HIF-1α阳性表达明显高于无淋巴结转移、Dukes分期为A、B期患者(P<0.05);CD34与HIF-1α的阳性表达存在一致性。结论 HIF-1α的过表达在结肠癌的发生发展及浸润转移过程中起着重要作用;HIF-1α参与结肠癌患者的肿瘤新生血管生成过程。Objective To investigate the expression and significance of hypoxia-induced factor-1α（HIF-1α） and microvescular density（MVD） in patients with colon cancer.Methods HIF-1α and CD34 were analyzed with immunohistochemistry in 46 colon cancer specimens and their tumor-adjacent normal colon tissues.The association between the expressions of HIF-1α and CD34 with the clinical and pathological characteristics of the patients was analyzed.Results The expression of CD34 was higher in colon cancer than that in tumor-adjacent normal colon tissues.The expressions of CD34 and HIF-1α in colon cancer were higher in cases with metastasis of lymph node,Dukes stages of C and D（P0.05）.The positive expression of CD34 was in accordance with HIF-1α.Conclusion HIF-1α expression is significantly associated with metastasis and invasion of colon cancer.HIF-1α expression is also involved in the formation of angiogenesis in tumor tissue.

关 键 词：结肠癌 低氧诱导因子1Α CD34 

分 类 号：R735[医药卫生—肿瘤]