Kindlin家族成员研究进展  

Progresses in The Studies on Kindlin Family Members

作　　者：熊盈[1] 龚小卫[1] 姜勇[1] 

机构地区：[1]南方医科大学病理生理学教研室和广东省蛋白质组学重点实验室,广州510515

出　　处：《生物化学与生物物理进展》2010年第12期1265-1270,共6页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)(2010CB529704);教育部长江学者和创新团队发展计划(PCSIRT)(IRT0731);国家自然科学基金(30700291);国家自然科学基金委员会-广东省联合基金重点项目(U0632004)资助项目~~

摘　　要：Kindlin是一族新发现的黏着斑蛋白,包括Kindlin-1、Kindlin-2和Kindlin-3三个成员.不同Kindlin家族成员在进化上具有高度同源性和保守性,参与了多种重要细胞生理过程,例如细胞迁移、增殖和分化的调控.Kindlin通过与β整合素胞内段的相互作用,在细胞-细胞外基质黏附、细胞-细胞间连接、细胞骨架重构以及整合素介导的双向信号传递中都具有重要作用.Kindlin家族成员的异常与多种遗传性疾病、心血管疾病及肿瘤的发生和发展密切相关.Kindlin与整合素作用机制的深入研究,不但可以丰富对细胞黏附和迁移的理论认识,而且将有助于临床上相关疾病的治疗.Kindlins are a group of newly identified focal adhesion proteins,including Kindlin-1,Kindlin-2,and Kindlin-3.Kindlins possess high homogeneity and conservation evolutionarily,involving in the regulation of many important cellular physiological functions,such as cell migration,proliferation,and differentiation.Through the interaction with the cytoplasmic domain of β integrin,Kindlins play important roles in cell-extracellular matrix adhesion,cell-cell junctions,cytoskeleton remodeling,and integrin-mediated bidirectional signaling.Abnormities of Kindlins are associated with the etiology and progression of some genetic diseases,cardiovascular diseases,and cancers.The further elucidation of the mechanisms regulating the cellular functions mediated by the interaction between Kindlins and integrins will not only improve our knowledge about cell adhesion and migration,but also the therapeutics of Kindlins-related diseases.

关 键 词：Kindlin 整合素 细胞黏附 信号转导 

分 类 号：Q291[生物学—细胞生物学] R394[医药卫生—医学遗传学]