腌制沙芥提取物镇痛和镇咳活性研究  

Effects of analgesia and antitussive of pickled Pugionium cornutum(L.) Gaertn

作　　者：李聪[1] 惠琅[1] 白斌[1] 申烨华[1] 兰梅[2] 张驰[3,4] 

机构地区：[1]西北大学合成与天然功能分子化学教育部重点实验室,新药研究所,化学与材料科学学院,陕西西安710069 [2]绍兴文理学院附属医院,浙江绍兴312000 [3]西安科技大学地质与环境学院,陕西西安710054 [4]神木县生态保护建设协会,陕西神木719300

出　　处：《西北大学学报（自然科学版）》2010年第6期999-1003,共5页Journal of Northwest University（Natural Science Edition）

基　　金：国家自然科学基金资助项目(20975079);浙江省自然科学基金资助项目(Y207007);国家基础科学人才培养基金资助项目(J0830417);陕西省教育厅产业化培育基金资助项目(05CJ30)

摘　　要：目的研究腌制沙芥水提取物和醇提取物的镇痛、镇咳活性,深入开发利用沙芥。方法通过小鼠热板和扭体实验,考查其镇痛作用;采用浓氨水喷雾实验研究其镇咳作用。结果热板和扭体实验表明,腌制沙芥提取物能明显抑制由物理和化学刺激引起的疼痛,且水提取物的活性大于醇提取物;浓氨水喷雾实验显示腌制沙芥提取物具有一定的镇咳作用,且醇提取物活性大于水提取物。结论腌制沙芥提取物具有良好的镇痛、镇咳作用。这为腌制沙芥应用于治疗疼痛、咳嗽提供了药理学实验依据。Aim To investigate the effects of analgesia and antitussive of the extracts of pickled Pugionium cornutum Gaertn.Methods Experiment for analgesia effect was done by using hot-plate test and acetic acid-induced writhing method.The antitussive effect was observed by mouse cough model induced by concentrated ammonia.Results Extract of pickled Pugionium cornutum Gaertn.can inhibite the pain induced by physical and chemical stimulation significantly,but the water extract is more effective than ethanol extract.It also has antitussive effect and the ethanol extract is more effective than water extract.Conclusion The extract of pickled Pugionium cornutum Gaertn.has effects of analgesia and antitussive.This conclusion can provide pharmacologic experimental evidence for its practical application.

关 键 词：沙芥 腌制 镇痛 镇咳 

分 类 号：R285.5[医药卫生—中药学]