HDAC6在胃癌组织中的表达  被引量:2

Role of histone deacetylase 6 in gastric cancer

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作  者:李群[1] 胡卫红[1] 李斌[1] 穆宝忠[1] 李鹏[1] 杨海军[1] 于安星[1] 吴贤臻[1] 

机构地区:[1]潍坊医学院附属平度市人民医院普外一科,山东潍坊266700

出  处:《中国现代普通外科进展》2010年第11期855-857,共3页Chinese Journal of Current Advances in General Surgery

基  金:青岛市卫生局科研基金支持项目(2008-wszd144)

摘  要:目的:检测胃癌组织与正常胃组织中组蛋白去乙酰化酶6(HDAC6)的表达,探讨HDAC6表达与胃癌发生的关系。方法:采用免疫组织化学方法,检测40例胃癌组织与36例正常或良性病变胃组织中HDAC6的表达。结果:HDAC6在40例胃癌组织中呈高表达25例,低表达15例。而良性病变胃组织中高表达10例,低表达26例。结论:HDAC6在胃癌组织中呈过表达状态。Objective:To investigate the expression and it's clinical significance of histone deacetylase 6 in gastric cancer tissue and gastric benign lesion.Methods: The expression of HDAC6 in 40 cases of surgically resected gastric cancer tissues and 36 cases gastric benign lesion were detected by immunohistochemistry.Results: In 40 cases of gastric carcinoma,HDAC6 was highly expressed in 25 cases,and 15 patients were with low expression.Gastric tissue of benign lesions was highly expressed in 10 cases,26 cases were with low expression.Conclusion: There is overexpression of HDAC6 in gastric cancer tissue and correlated with the clinicopathologic factors above mentioned.

关 键 词:组蛋白去乙酰化酶6 胃肿瘤 免疫组织化学 

分 类 号:R735.2[医药卫生—肿瘤]

 

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