Cx43、ILK蛋白的表达与卵巢上皮性肿瘤生物学行为的关系  

Relation of Cx43、ILK Expression with Biologic Behavior of Ovarian Epithelial Tumor

作　　者：李胜水[1] 卢智[1] 张红艳[1] 刘岩[1] 李双标[1] 张凤梅[1] 高秀敏[1] 许华[1] 

机构地区：[1]河北省沧州中西医结合医院病理科,河北沧州061001

出　　处：《中外医疗》2010年第34期12-13,共2页China & Foreign Medical Treatment

摘　　要：目的 Cx43、ILK蛋白在不同类型、不同分期的卵巢上皮性肿瘤的表达情况。方法采用S-P法免疫组化染色观察Cx43、ILK蛋白在37例卵巢良性肿瘤、33例卵巢交界性肿瘤和69例卵巢上皮癌的表达情况。结果在卵巢癌中Cx43蛋白表达阳性率降低;ILK表达阳性率增高。Cx43蛋白表达与组织学类型无关;而ILK在粘液性癌表达阳性率与浆液性癌和子宫内膜样癌比较,差异显著。Cx43蛋白和ILK在不同分化程度卵巢癌中的表达无显著差异。Cx43蛋白在Ⅰ～Ⅱ期癌表达阳性率均高于Ⅲ～Ⅳ期癌,ILK在Ⅲ～Ⅳ期癌表达阳性率高于Ⅰ～Ⅱ期癌。结论 Cx43表达缺失及ILK的过度在卵巢癌的发生和发展中可能都起重要作用。objective Our purpose was to study the expression of Cx43 and ILK in ovarian epithelial tumor.Methods Compared with normal ovary,the expression of Cx43 and ILK was observed immunohistochemically on formalin-fixed paraffin embedded sections in 37 cases of ovarian benign tumor,33 cases of ovarian borderline tumor and 69 cases of ovarian epithelial carcinoma.Results The positive rate of Cx43 protein was lower and that of ILK was higher in ovarian carcinoma.The present of Cx43 protein was not related to histological types of tumor.The mucous carcinoma differed significantly from serous and endometrioid carcinoma in positive rate of ILK.Among ovarian carcinoma,the expression of Cx43 and ILK was not related to differentiation of the tumor.The positive rates of Cx43 were higher in stageⅠto Ⅱcarcinoma than in stage Ⅲ to Ⅳ carcinoma.which of ILK were higher in stage Ⅲ to Ⅳ carcinoma than in stageⅠto Ⅱcarcinoma.Conclusion Inactive of Cx43 and the high expression of ILK are involed in the genesis and progression of ovarian carcinoma.

关 键 词：卵巢肿瘤 免疫组织化学 CX43 ILK 

分 类 号：R737.31[医药卫生—肿瘤]