双孔钾离子通道TREK-1在宫颈癌中的表达  

Expression of two-pore domain potassium channel TREK-1 in cervical carcinoma

作　　者：董晓宇[1] 

机构地区：[1]南京医科大学基础医学院,江苏南京210029

出　　处：《中国中医药咨讯》2010年第34期75-76,共2页

摘　　要：目的：TREK-1是双孔钾离子通道蛋白家族成员，可能与肿瘤的发生、发展密切相关。本文旨在探讨TREK-1在宫颈癌中的差异表达。方法：用免疫组化技术分析TREK-1在30例正常宫颈组织和30例宫颈癌组织中的表达，分析其差异与多项临床指标之间的相关性。结果：TREK-1在宫颈癌组织中的表达显著上调，其表达与组织学分级、临床分期及有无淋巴结转移无明显相关。结论：TREK-1可能具有促进宫颈癌进展的作用。Objective： TREK- 1 is a member of the two-pore domain potassium channel family, and may be associated with patho-genesis and progressian of tumor. The aim of this study was to explore the expression of TREK-1 in cervical carcinoma. Methods： Immunohistochemistry was performed to analyze the different expression of TREK-1 in 30 normal cervical tissues and 30 cervical carcinoma samples. We then analyzed the relations between TREK-1 expression and muhiple clinical parameters. Results： TREK-1 was significant- ly up-regulated in cervical carcinoma relative to normal cervical tissues. There were no significant correlations of TREK-1 expression with grade of differentiation, TNM stage and lymph node metastasis. Conclusion： Our results suggest that TREK-1 could promote the progression of cervical carcinoma.

关 键 词：宫颈癌组织 钾离子通道 双孔 免疫组化技术 无淋巴结转移 组织学分级 家族成员 通道蛋白 

分 类 号：R737.33[医药卫生—肿瘤]