用ROC曲线确定D-二聚体定量结果诊断NS、HSP的临界值及其意义  

作　　者：庄文胜[1] 

机构地区：[1]福建医科大学附属南平市第一医院,福建南平353000

出　　处：《中国中医药咨讯》2010年第34期76-77,共2页

摘　　要：目的：使用ROC曲线确定D-二聚体定量适合于NS、HSP的诊断临界值，并重新评价其临床意义。方法：按照NS、HSP诊断标准收集D-二聚体定量榆查的患者标本，用免疫比浊法测D-二聚体含量，根据结果绘制ROC曲线，并应用统计软件进行分析。结果：D-二聚体用于NS、HSP的诊断临界值分别为1．2μg／m1（敏感度为86．42％，特异性为54．55％），0．98μg/ml（敏感度为68．75％％，特异性为61．44％）。结论：本文确定的NS、HSP的诊断临界值，相对于试剂盒推荐的以0．5μg／ml作为诊断临界值具有更好的准确性，对于进一步提高临床诊断的效率具有显著意义。Objective Use ROC curve to find out the diagnosis cut-off point of NS,HSP by D-dimcr content and reappraises its clinical significance. Method According to NS ,HSP diagnosis standard coiled the patients＇ specimen, use immunoturbidimetric methods measured the D- dimer content, draws up the ROC curve according to the result, and carries on the analysis using statistical software. Result the D- dimer content cul-off point of NS, HSP clinical diagnosis are 1.2 μg/ml （sensitivity is 86.42%, specificity is 54.55%）, 0.98μg/ml （sensitivity is 68.75%%, specificity is 61.44%）. Conclusion The cut-off point determinded by this research compare to 0.5μg/ml which provides by the reagent box as the diagnosis standard has a better accuracy, have the remarkable significance in improving the clinical diagnosis efficiency

关 键 词：ROC D-聚体 肾病综合征 过敏性紫癜 

分 类 号：R542.22[医药卫生—心血管疾病]