The Central Government Guides Local Science and Technology Development Fund,No.2023JH6/100100021;Liaoning Province Education Department Foundation of China,No.JYTMS20231393 and No.LJ212410164032;Scientific Research Project of the Liaoning Province Education Department,No.SYYX2019015;Science and Technology Foundation of Shenyang Medical College,No.20171004;the Science and Technology Innovation Fund for Master Students of Shenyang Medical College,No.Y20220509.
BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality worldwide.This study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocur...
This work was funded by Ministry of Science and Technology of the People’s Republic of China(2020YFA0909200 to P.L.);Zhejiang Provincial Natural Science Foundation of China(LR23C050001 to P.L.);“Pioneer”and“Leading Goose”R&D Program of Zhejiang(2024SSYS0036);the National Natural Science Foundation of China(22137005 to L.L.and P.L.);China Postdoctoral Science Foundation project(2021M692883 to B.Z.);the Fellowship of Zhejiang Province Postdoctoral Science Foundation(ZJ2022006);the Research Center for Industries of the Future(RCIF)at Westlake University.
Abiotic d-proteins that selectively bind to natural l-proteins have gained significant biotechnological interest.However,the underlying structural principles governing such heterochiral protein–protein interactions r...