晚期胰腺癌的疗效评价及生存相关因素分析  

Treatment evaluation and analysis of survival-related factors in advanced pancreatic cancer

作　　者：刘建强[1] 高军[1] 黄浩杰[1] 王卫卫[1] 李兆申[1] 

机构地区：[1]第二军医大学附属长海医院,上海200433

出　　处：《山东医药》2010年第47期1-2,共2页Shandong Medical Journal

基　　金：国家科技支撑计划资助项目(2006BAI02A12)

摘　　要：目的分析晚期胰腺癌患者的综合治疗效果及预后影响因素。方法回顾性分析96例晚期胰腺癌Ⅲ、Ⅳ期患者的治疗方法及效果,采用Cox比例风险模型进行生存率多因素分析。结果 66例行化疗、靶向治疗、粒子种植者生存时间长于仅行营养支持及对症治疗者,但无统计学意义。粒子种植可提高Karnofsky评分(P<0.05),降低疼痛VAS评分(P<0.01)。多因素分析显示年龄<60岁、胰头肿瘤、肿瘤直径>4 cm、有远处转移者生存期短(P<0.05)。结论肿瘤直径>4 cm、有远处转移等因素是影响晚期胰腺癌预后的主要因素。粒子种植治疗可显著缓解症状、提高生存质量。Objective To analyze the effect of comprehensive treatment and the prognostic factors in patients with advanced pancreatic cancer. Methods The therapy method and its effect of 96 advanced pancreatic cancer patients with clinical stage Ⅲ and Ⅳ were analyzed retrospectively, and then the Cox proportional hazards model were used to make the multivariate survival analysis. Results Compared with 30 patients received only nutritional support and simple treatment, the survival time of 66 patients received routine chemotherapy, targeted therapy and iodine seeds implantation prolonged, but no significance was found. Iodine seeds implantation therapy improved the Kamofsky scores（P 〈 0.05 ） , and reduced pain VAS score （P 〈 0.01 ）. Multivariate analysis showed that patients younger than 60 years, with pancreatic head tumors, tumor size 〉 4 cm, distant metastasis had a shorter survival time （ P 〈 0.05 ）. Conclusions Tumor size 〉 4 cm, distant metastasis and other factors have significant effects on the prognosis and survival of advanced pancreatic cancer patients. Io- dine seeds implantation can relieve symptoms and improve quality of life.

关 键 词：胰腺肿瘤 晚期 预后 生存期 粒子种植 靶向治疗 

分 类 号：R735.9[医药卫生—肿瘤]