鼻咽癌患者血清中VEGF-C和CYFR21-1的表达及其与淋巴转移的关系  

Expression and significance of VEGF-C and CYFR21-1 in serum from patients with nasopharyngeal cancer

作　　者：田峰 文道林 齐素文[2] 王林纤[2] 

机构地区：[1]深圳市公明人民医院检验科,广东深圳518053 [2]重庆医科大学医学检验系,重庆400016

出　　处：《海南医学》2011年第1期11-12,6,共3页Hainan Medical Journal

基　　金：广东省深圳市科技计划项目基金(编号:201003470)

摘　　要：目的探讨鼻咽癌(NPC)患者外周血血清中血管内皮生长因子(VEGF-C)和细胞白蛋白19片段(CYFR21-1)表达水平和意义。方法运用酶联免疫吸附测定法定量检测35例鼻咽癌患者、30例鼻咽部良性疾病患者和30例健康人血清中VEGF-C含量;运用化学发光免疫分析法检测上述病例的CYFR21-1水平。结果鼻咽癌患者血清中VEGF-C和CYFR21-1表达水平与良性疾病对照组、健康对照组比较,差异有统计学意义[VEGF-C:(426.45±240.59)ng/Lvs(141.54±109.12)ng/L,(114.45±35.45)ng/L];CYFR21-1:(12.80±0.86)ng/mlvs(3.48±0.48)ng/ml,(3.12±0.80)ng/ml,P均<0.05)。VEGF-C和CYFR21-1在各类鼻咽癌中表达水平分别为:鳞癌为(512.02±151.45)ng/L和(12.80±0.87)ng/mL,腺癌为(402.87±240.16)ng/L和(10.80±0.86)ng/mL,未分化癌为(432.32±340.57)ng/L和(9.80±0.86)ng/mL]。VEGF-C和CYFR21-1的表达在淋巴结转移组均高于无转移组(P<0.05),且二者表达成正相关(r=0.756)。结论 VEGF-C和CYFR21-1在鼻咽癌患者血清中表达水平增高,且与鼻咽癌淋巴结转移相关。Objective To investigate the expressions and significance of vascular endothelial growth factor （VEGF-C）and cytokeratinl 9 fragment（CYFR21-1）in serum from nasopharyngeal cancer patients.Methods The levels of serum VEGF-C and CYFR21-1 in 35 cancer patients,30 patients with benign nasopharyngeal diseases and 30 healthy controls were measured by enzyme-linked immunosorbent assay （ELISA） and chemiluminescence immunoassay,respectively.Results The levels of serum VEGF-C and CYFR21-1 in nasopharyngeal carcinoma patients were significantly higher than those in patients with benign nasopharyngeal diseases and healthy controls （VEGF-C：426.45± 240.59 ng/L vs 141.54±109.12 ng/L,114.45±35.45 ng/L;CYFR21-1：12.80±0.86ng/mL vs 3.48±0.48 ng/mL,3.12±0.80 ng/mL,all P0.05）.The level of VEGF-C and CYFR21-1 in three types of nasopharyngeal cancer were as following：squamous cance（r512.02±151.45 ng/L,12.80±0.87 ng/mL）,adenocarcinoma（402.87±240.16 ng/L,10.80±0.86 ng/mL） and undifferentiated carcinoma （432.32±340.57 ng/L,9.80±0.86 ng/mL）.There were significant different expressions of VEGF-C and CYFR21-1 between the patients with lymph node-positive group and node-negative group （both p0.05）.In addition,the expressions of them were positively correlated （r=0.756）.Conclusion VEGF-C and CYFR21-1 expressed highly in serum of nasopharyngeal cancer patients and have a close relationship with lymph node metastasis.

关 键 词：鼻咽癌 VEGF-C CYFR21-1 

分 类 号：R739.63[医药卫生—肿瘤]