高压氧对咽喉肿瘤术后创口延迟愈合的治疗作用  

The effect of hyperbaric oxygen therapy on treatment of late healed wounds after pharyngeal and laryngeal surgery

作　　者：姜玮玮[1] 梁大鹏[1] 张海琴[2] 尚伟[3] 王培嵩[4] 李薇[1] 

机构地区：[1]青岛大学医学院附属医院耳鼻咽喉头颈外科,山东青岛266003 [2]杭州师范大学附属医院耳鼻咽喉科 [3]青岛大学医学院附属医院口腔颌面外科,山东青岛266003 [4]青岛大学医学院附属医院高压氧科,山东青岛266003

出　　处：《临床耳鼻咽喉头颈外科杂志》2011年第1期14-15,19,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨高压氧(HBO)对咽喉肿瘤术后创口延迟愈合的治疗作用。方法:口咽癌、喉咽癌、喉癌手术治疗后伤口延迟愈合患者83例,其中48例行HBO综合治疗(HBO综合治疗组),压力取2×105Pa,110min/次,每天1次,5～10次为1个疗程。35例常规换药综合治疗进行对照(常规换药组)。结果:HBO治疗3～4次后,创面即有新鲜肉芽生成,其后纤维肉芽和毛细血管不断生成充填创面,直至创口愈合,其中皮瓣坏死愈合平均时间为27.50d,咽瘘为8.50d,创腔积液或感染为5.93d;常规换药组皮瓣坏死为45.00d,咽瘘为14.09d,创腔积液或感染为8.62d。2组平均愈合时间比较均差异有统计学意义(均P<0.01)。结论:HBO对咽喉肿瘤术后伤口延迟愈合患者有明显的治疗作用,可促进伤口愈合。Objective：To investigate effect of hyperbaric oxygen（HBO） therapy on treatment of late healed wounds after pharyngeal and laryngeal carcinomas surgery.Method：Eighty-three patients with late healed wounds after pharyngolaryngectomy were divided into tow groups, which were HBO treatment group（n=48） and control group（n=35） by random. 48 cases were treated with the general therapeutic measure along with HBO（the pressure is 2×105 Pa, 110 minutes per day for 5 to 10 days）. The other 35 cases were treated with the general therapy without HBO as control.Result：There were fresh granulation erupted from the wound of entry after 3 or 4 days of HBO treatment, then the granulation and the new blood capillary erupted continually to fill the wound surface, and the wound of entry was healed over finally. In the HBO and the control groups, the average healing time was 27.50 and 45.00 days（P〈0.01） in the wound by necronectomy of the myocutaneous flap or forearm flap, 8.50 and 14.09 days（P〈0.01） in the pharyngeal fistula, 5.93 and 8.62 days（P〈0.01） in the infected or fluid-filled wound.Conclusion：HBO therapy is an effective and powerful treatment for late healed postoperative wounds in pharyngeal and laryngeal carcinomas surgery.

关 键 词：高压氧 咽肿瘤 喉肿瘤 伤口愈合 手术 

分 类 号：R739.6[医药卫生—肿瘤]