诊断性宫腔镜与子宫内膜癌腹水肿瘤细胞播散相关性荟萃分析  

A meta-analysis of the relationship between peritoneal cytology and diagnostic hysteroscopy in endometrial carcinoma

作　　者：顾广宇[1] 侯宗萍[1] 钱永红[1] 

机构地区：[1]南京医科大学附属苏州医院(苏州市立医院本部)妇产科,苏州215000

出　　处：《中国妇幼卫生杂志》2011年第1期25-28,共4页Chinese Journal of Women and Children Health

摘　　要：目的通过对有关宫腔镜应用与子宫内膜癌的临床对照研究资料进行荟萃分析(meta分析),探讨诊断性宫腔镜应用于早期子宫内膜癌患者后,是否会增加肿瘤细胞在腹水中的播散。方法检索1990年1月至2009年12月PUBME、EMBASE、中国生物医学文献数据库上公开发表的有关宫腔镜应用与子宫内膜癌和收集到的腹水或腹腔冲洗液中肿瘤细胞阳性或可疑阳性例数关系的文献,按照入选和排除标准,共有9篇临床对照试验纳入本研究,对其研究内容摘录后应用RevMan4.2软件进行分析。结果诊断性宫腔镜应用于子宫内膜癌患者后,与对照组比较有增加阳性腹水肿瘤细胞例数的风险,OR值为1.79,95%CI为(1.25,2.57)。结论根据现有的临床对照研究资料分析,宫腔镜可能增加子宫内膜癌肿瘤细胞的腹腔内播散,故宫腔镜推广应用于子宫内膜癌患者的诊断尚需谨慎。Objective The aim of the study is to perform a meta-analysis of available clinical controlled trials,to evaluate whether the diagnostic hysteroscopy will increase the risk for intraperitoneal cancer cell dissemination in patients with clinically early-stage endometrial cancer. Methods The literature about the association of hysteroscopy and peritoneal cytology obtained from endometrial carcinoma were searched for according to inclusion and exclusion criteria from January of 1990 to December of 2009. The data in the nine controlled studies selected were analyzed by RevMan 4.2 software. Results In patients with endometrial carcinoma,the performance of diagnostic hysteroscopy will increase the positive incidence of peritoneal cytology（odd ratio 1.79,95% confidential intervals 1.25 to 2.57）. Conclution According to the achieved controlled trials＇ data,Hysteroscopy used in the diagnosis of endometrial carcinoma may facilitate the tumor cell dissemination. Thus,we should be more circumspect in expanding it.

关 键 词：子宫内膜癌 宫腔镜 腹水细胞学 播散 META分析 

分 类 号：R737.33[医药卫生—肿瘤]