脱氢枞胺(4-羟基)水杨醛Schiff碱β-环糊精包合物的制备与表征  

Characterization and preparation of dehydroabietylamine 4-hydroxy-salicylidene Schiff base β-cyclodextrin inclusion complex

作　　者：陈泳[1] 林中祥[2] 张丹红[1] 

机构地区：[1]南京林业大学理学院,江苏南京210037 [2]南京林业大学化学工程学院,江苏南京210037

出　　处：《南京林业大学学报（自然科学版）》2011年第1期62-66,共5页Journal of Nanjing Forestry University：Natural Sciences Edition

基　　金：国家自然科学基金项目(30771688)

摘　　要：采用饱和溶液法制备了脱氢枞胺(4-羟基)水杨醛Schiff碱β-环糊精包合物,通过红外光谱、差示扫描量热法(DSC)以及紫外光谱对包合物进行鉴定,并对脱氢枞胺(4-羟基)水杨醛Schiff碱及其包合物的抗癌活性进行了研究。结果表明:脱氢枞胺(4-羟基)水杨醛Schiff碱和环糊精可形成摩尔比为1∶1的包合物;β-环糊精可以将脱氢枞胺(4-羟基)水杨醛Schiff碱在混合溶剂(V(DMSO)∶V(H2O)=1∶1)中的溶解度提高3.4倍;在质量浓度为10μg/mL时,脱氢枞胺(4-羟基)水杨醛Schiff碱及其包合物对卵巢癌细胞株(Hey-1B)的抑制率分别达到50.34%和41.65%。Dehydroabietylamine 4-hydroxy-salicylidene Schiff base complexes enwrapped with β-cyclodextrin were prepared by the method of saturation solution,and were identified with IR,DSC and UV.The antitumor activities of the dehydroabietylamine 4-hydroxy-salicylidene Schiff base and the inclusion complexes were studied.The main results were as follows： The inclusion complex was formed at the 1∶1 molar ratio of dehydroabietylamine 4-hydroxy-salicylidene Schiff base and β-cyclodextrin;the solubility of dehydroabietylamine 4-hydroxy salicylidene Schiff base in mixed solvent（V（DMSO）∶V（H2O）=1∶1） was increased by 34 folds after complexing with β-cyclodextrin;the inhibitory ratios of the dehydroabietylamine 4-hydroxy-salicylidene Schiff base and its inclusion complex on ovarian cancer cell line（Hey-1B） were 50.34% and 41.65 %,respectively,at the concentration of 10 μg/mL.

关 键 词：脱氢枞胺(4-羟基)水杨醛Schiff碱 Β-环糊精 包合物 溶解度 

分 类 号：TQ351[化学工程]