丹栀逍遥散治疗复发性口腔溃疡的临床研究  

THE RESEARCH ON DANZHIXIAOYAOSAN FOR THE TREATMENT OF RECURRENT ORAL ULCER

作　　者：李晓荣[1] 

机构地区：[1]广东省深圳市第二人民医院口腔科,508010

出　　处：《中国煤炭工业医学杂志》2011年第1期101-102,共2页Chinese Journal of Coal Industry Medicine

基　　金：广东省中医药局建设中医药强省科技计划项目(2007247)

摘　　要：目的观察丹栀逍遥散治疗复发性口腔溃疡的临床疗效。方法将60例复发性口腔溃疡患者随机分为二组,对照组30例口服左旋咪唑片,复合维生素B片和维生素C片。治疗组在服用上述西药的同时加用丹栀逍遥散,同时,分别在试验1年后,采取受试者血样本,分别测试细胞因子TNF-α和IL-10水平。结果观察组有效率(93.3%)高于对照组(66.7%),差异有统计学意义(P<0.05)。观察组TNF-α水平(81.25±15.62)pg/ml明显低于对照组(146.32±21.47)pg/ml,而IL-10水平(296.58±23.55)则明显高于对照组(107.36±19.27)Pg/ml(P<0.05)。结论丹栀逍遥散治疗复发性口腔溃疡疗效可靠,能明显减少患者复发次数和程度,且无明显不良反应,值得临床推广。Objective In order to observe the therapeutic efficacy of Danzhixiaoyaosan to recurrent oral ulcer（ROU）.Methods Sixty patients with ROU were divided into two groups.One group for control,the other for Danzhixiaoyaosan test.In the meantime,the TNF-αand IL-10 were measured by ELISA.Results The remission rate of ROU reached 93.3% after Danzhixiaoyaosan treatment The remission rate of ROU reached 66.7% in control group.There was obvious difference between two groups.The level of TNF-α was reduced,but IL-10 was induced significantly（P〈0.05）.Conclusion Danzhixiaoyaosan has certain function to remit outbreak of ROU.

关 键 词：丹栀逍遥散 口腔溃疡 复发性 肿瘤坏死因子 白细胞介素10 中药治疗 

分 类 号：R781.5[医药卫生—口腔医学]