激光间质热疗的功能近红外疗效评估  

Therapy Effect Assessment by Functional Near Infrared Spectroscopy During Laser Induced Interstitial Thermotherapy

作　　者：钱爱平[1] 花国然[1] 钱志余[2] 周家华[3] 戴丽娟[1] 吕操君[1] 王晋阳[2] 王栋[3] 

机构地区：[1]南通大学机械工程学院,江苏南通226019 [2]南京航空航天大学生物医学工程系,江苏南京210016 [3]东南大学附属中大医院,江苏南京210009

出　　处：《中国激光》2011年第1期98-102,共5页Chinese Journal of Lasers

基　　金：江苏省自然科学基金(BK2008184);南通市自然科学基金(K2009044);南通大学自然科学基金(08Z019;09R06)资助课题

摘　　要：探讨了利用功能近红外光谱(FNIRS)实时在体监测激光诱导肿瘤间质热疗(LITT)进行疗效评估的可行性。实验采用新鲜离体猪肝和肝癌小鼠皮下移植瘤模型,按不同激光功率和加热时间进行LITT毁损热疗,利用FNIRS监测系统同时监测热疗过程中约化散射系数μs′。结果表明,FNIRS监测系统获取的约化散射系数在LITT热疗过程中呈上升趋势,起始阶段上升较快,达到一定数值后趋于稳定。激光功率越大,μs′上升越快。组织成分不一样时,约化散射系数的变化趋势一致,曲线形态有所不同。因此,FNIRS可以用于LITT实时在体疗效评估,μs′可以作为一种新的LITT术中实时在体疗效评估因子,通过监测μs′的变化将有助于指导临床热疗。To investigate the feasibility of in vivo effect assessment monitoring by functional near infrared spectroscopy （FNIRS） during laser induced interstitial thermotherapy （LITT） in real time, the reduced scattering coefficient during LITT therapy by different laser powers and heating time on Fresh pork liver in vitro and the subcutaneous implanted rat liver cancers by FNIRS system are recorded in vivo. The reduced scattering coefficient （μ′s） which gets through the FNIRS increases during LITT, it increases quickly at beginning, and gradually reaches the stable state.μ′s rises faster when the laser power is greater. There is the same changing trends ofμ′s of different tissues, but there is difference between the curve shapes. The system of FNIRS can be used to assess the therapy effect during laser induced interstitial thermotherapy in vivo, and μ′s can be used as a new effect assessment factor. By monitoring the changes of μ′s can effectively guide clinical therapy.

关 键 词：激光生物学 激光热疗 功能近红外光谱 约化散射系数 疗效评估 

分 类 号：Q631[生物学—生物物理学] R730.57[医药卫生—肿瘤]