体内可分解性高分子材料的研究:聚DL乳酸膜In Vitro降解特征  

Studies on biodegradable polymers in vitro degradation of poly(DL lactide)films

作　　者：张颖[1] 朴东旭[1] 毛立江[1] 

机构地区：[1]中国康复研究中心医用高分子研究室,北京100077

出　　处：《中国康复理论与实践》1999年第3期106-109,共4页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：本文主要讨论ＰＤＬＬＡ膜ｉｎ ｖｉｔｒｏ 降解的一些特征，用分子量、分散指数和失重率等表示降解的规律和趋势，并对其降解机理进行初步讨论，认为ＰＤＬＬＡ ｉｎ ｖｉｔｒｏ 降解是一个简单的酯键水解。In the paper,in vitro degradation of DL polylactic acid (PDLLA) film was studied.Regulation and tendency of degradation were showed by molecular weight regulator and monomer ration mass lossing.Degradation mechanism was discussed in light.It was thought that degradation of PDLLA in vitro was a simple hydrolysis reaction.The hydrolysis reaction was self catalytic reaction caused by terminal carboxyl group.

关 键 词：生物材料 PDLLA膜 降解 聚交酯 乳酸 分散指数 

分 类 号：R318.08[医药卫生—生物医学工程]