乳酸杆菌对小鼠巨噬细胞受体介导内吞及抗肿瘤作用的研究  

The study on the effects of RME and antitumor of lactobacillus on macrophage of mice

作　　者：任力 葛凤霞 袁小林 曾汉英 陈爱娟 张训有 于桂臣 候朝晖 

机构地区：[1]空军医学高等专科学校病理教研室,吉林132013 [2]大连市第三人民医院肿瘤研究室

出　　处：《吉林医学院学报》1999年第1期19-21,共3页

摘　　要：目的：探讨乳酸杆菌对小鼠巨噬细胞免疫功能的影响。方法；采用免疫电镜，放射免疫及ＥＬＩＳＡ法，分别观察小鼠巨噬细胞的ＲＭＥ，体内外细胞毒作用及ＴＮＦ活性情况。结果：实验组小鼠巨噬细胞ＲＭＥ明显增强，巨噬细胞体内外毒性明显增高。结论：乳酸杆菌对小鼠巨噬细胞的免疫功能具有增强的调节作用，可提高巨噬细胞对肿瘤细胞的杀伤功能。Objective: To study the immune function of Lactobacillus on macrophage of mice. Methods: Immunoelectronic microscopy, autoradiography and ELISA method were used to observe the RME, the cytotoxicity of peritoneal macrophage in vitro and in vivo and changes of TNFα, respectively. Results: The RME function was enhanced markedly afer injection of Lactobacillus, the cytotoxicity of peritoreal macrophage in vitro and in vivo enhanced and the secretion of TNFαwas higher than comtrol groups ( P < 0.01). Conclusion: Lactobacillus can regulate the function of macropjhage of mice and enhance the ability of macrophage to kill the tumor cells.

关 键 词：乳酸杆菌 受体介导内吞 巨噬细胞 抗肿瘤 

分 类 号：Q939.117[生物学—微生物学] R73－36[医药卫生—肿瘤]