青少年代谢综合征因子分析  

Factor analysis of the metabolic syndrome in adolescents

作　　者：孙玉叶[1] 张慧颖[2] 于伟平[1] 

机构地区：[1]扬州市妇幼保健院儿童保健科,江苏扬州225002 [2]哈尔滨医科大学公共卫生学院儿少卫生与妇幼保健学教研室,黑龙江哈尔滨150086

出　　处：《中国儿童保健杂志》2011年第2期134-136,148,共4页Chinese Journal of Child Health Care

摘　　要：【目的】通过青少年代谢综合征(metabolic syndrome,MS)相关组分的因子分析,探索青少年MS病理生理机制。【方法】以哈尔滨市某校130名高一学生为研究对象。测量身高、体重、腰围、臀围、收缩压、舒张压,计算体质指数、腰臀比和腰围身高比;测定空腹血糖、血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及血清超敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)含量。【结果】未引入hs-CRP变量时,提取三个公因子:肥胖因子、脂代谢因子和血压血糖因子,分别解释10个原始变量的31.730%、22.287%和16.767%,累计方差贡献率为70.784%。引入hs-CRP变量后,青少年MS相关组分共提取3个因子,分别为肥胖因子、脂代谢因子和血压血糖因子,分别解释10个原始变量的32.697%、20.275%、15.454%,累计方差贡献率为68.427%。【结论】肥胖因子在青少年MS发病机制中起主要作用;腰围身高比较腰围更适于评价青春期MS的中心性肥胖;hs-CRP可能参与青春期MS的发病。【Objective】 To identify the clustering characteristics of metabolic syndrome（MS） and to explore the mechanisms of it in adolescents by factor analysis. 【Methods】 130 students were sampled from a senior high school in Harbin.The height,weight,waist circumference,blood pressure（BP）,the body mass index（BMI） and the waist-to-height ratio（WHtR） were measured or calculated.The FPG,TC,TG,HDL-C,and LDL were detected by automatic biochemical analyzer.The hs-CRP was detected.Spearman correlation and factor analysis were used by SPSS17.0 program. 【Results】 Without the hs-CRP,principal component factor analysis revealed three factors： adiposity,lipid-metabolic,blood pressure and carbohydrate-metabolic that cumulatively explained 70.784% of the observed variance of metabolic syndrome;With the hs-CRP,it revealed three factors： adiposity lipid-metabolic,blood pressure and carbohydrate-metabolic（DBP,SBP,FPG） that cumulatively explained 68.427% of the observed variance of metabolic syndrome. 【Conclusions】 Adiposity plays a major role in the pathogenesis of MS in adolescents;WHtR is more suitable for evaluating central obesity of MS in adolescents than WC;hs-CRP may be involved in the pathogenesis of MS in adolescents.

关 键 词：代谢综合征 因子分析 超敏C反应蛋白 青少年 

分 类 号：R725.8[医药卫生—儿科]