新城疫病毒联合热固化瘤苗抗小鼠肿瘤作用探讨  

STUDY ON ANTI TUMOR ROLE OF NEWCASTLE DISEASE VIRUS COMBINED THERMIC SOLIDIFIED TUMOR VACCINE IN RATS

作　　者：李小军[1] 白艳婷[1] 田伏洲[1] 刘晓波[1] 尹致良[1] 

机构地区：[1]成都军区总医院普外中心

出　　处：《中国普外基础与临床杂志》1999年第5期276-277,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：为探讨新城疫病毒（简称 Ｎ Ｄ Ｖ）联合热固化瘤苗对小鼠肿瘤的抑瘤作用和免疫调节作用，实验检测了荷瘤小鼠的抑瘤率和细胞免疫功能。实验将接种上 Ｓ Ｐ２／０ 及 Ｈ２２ 瘤细胞的荷瘤小鼠分为单纯 Ｎ Ｄ Ｖ 治疗组（实验Ⅰ组）和 Ｎ Ｄ Ｖ＋ 热固化瘤苗治疗组（实验Ⅱ组）。结果显示： 实验Ⅰ组与实验Ⅱ组抑瘤率分别为 ２４．８％ 和 ４１．１％ ，两组的平均瘤重明显小于对照组，且实验Ⅰ组和实验Ⅱ组在不同时段的自然杀伤（ Ｎ Ｋ）细胞活性均高于对照组（ Ｐ＜ ０．０１），实验Ⅱ组的抑瘤率和 Ｎ Ｋ 细胞活性比实验Ⅰ组更高。提示 Ｎ Ｄ Ｖ 联合热固化瘤苗对荷瘤小鼠的抑瘤作用和增强 Ｎ Ｋ 细胞活性均比单独应用 Ｎ Ｄ Ｖ 的效果好。In this study, the role of newcastle disease virus (NDV) combined thermic solidified tumor vaccine in inhibiting growth of tumor and immune control was investigated, and rate of inhibiting tumor and cellular immunity were measured. The results showed that rate of inhibiting tumor in experimental group Ⅰ and Ⅱ were 24.8% and 41.1% respectively; average weight of tumor was significantly lower in both experimental groups than in control group, and activity of natural killing (NK) cells in experimental groups was higher than that in control group ( P <0.01). This suggests that NDV combined thermic solidified tumor vaccine can inhibit growth of tumor and improve activity of NK cells, and their effects are better than that of NDV.

关 键 词：新城疫病毒 热固化瘤苗 抗肿瘤作用 

分 类 号：R730.51[医药卫生—肿瘤]