β-环糊精包合活血舒筋贴膏中挥发油的正交试验研究  

Study on β-Cyclodextrin Inclusion of Volatile Oil in Huoxue Shujin Strapping Through Orthogonal Experiment

作　　者：张丽芬[1] 刘志承[1] 朱国婵[1] 索娟[1] 

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《中药新药与临床药理》2011年第1期114-116,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：深圳市科技计划立项项目(201003186)

摘　　要：目的优化活血舒筋贴膏中挥发油β-环糊精包合工艺条件。方法以挥发油包合率、包合物收率为指标,采用正交试验方法优选搅拌法制备挥发油β-环糊精的最佳包合工艺条件。结果最佳包合工艺条件为:挥发油与β-环糊精比例为1∶8(mL∶g);包合时间为40 min;包合温度为60℃。结论优选出的工艺包合率和包合物收率均较高,工艺合理、可行。Objective To optimize β-cyclodextrin inclusion process for the inclusion of volatile oil in Huoxue Shujin Strapping. Methods After β-cyclodextrin inclusion complex was prepared by stirring method, orthogonal experiment was performed for the optimization of β-cyclodextrin inclusion process, and inclusion rate of volatile oil, recovery rate of inclusion compound were used as indexes. Results The optimized inclusion conditions were as follows： the ratio of volatile oil to β-cyclodextrin was 1 ： 8 （mUg）, the inclusion temperature was at 60 ℃ and inclusion time lasted 40 min. Conclusion The optimized method is efficient, reliable and feasible, with high yieht of inclusion complex.

关 键 词：活血舒筋贴膏 挥发油 Β-环糊精 正交试验 包合物 

分 类 号：R284.2[医药卫生—中药学]