热休克蛋白HSP60基因在耐药白血病中的表达研究  

作　　者：雷博[1] 

机构地区：[1]西安交通大学医学院第二附属医院血液科,710004

出　　处：《当代医学》2011年第3期44-45,共2页Contemporary Medicine

摘　　要：目的探讨HSP60基因在白血病患者中的表达水平,并分析其与临床特征的关系。方法应用实时荧光定量R-PCR方法检测HSP60基因在白血病耐药组、敏感组及正常组中的表达水平并加以比较。结果 HSP60mRNA在白血病组的表达明显高于正常组,在耐药组明显高于敏感组,在ALL和AML患者中的表达没有明显差异。结论 HSP60基因有可能为新的白血病耐药相关基因。Objective To investigate the expression level of gene HSP60 of patients with leukemia and the correlation with clinical features.Methods The expression level of gene HSP60 in drug-resistant,drug-sensitive patients of leukemia and healths were detected by real-time quantitative RT-PCR and compared each other.Results The expression of HSP60 gene in drug-resistant group higher than drug-sensitive group,in AL group higher than the healthy group,and it had nothing to do with FAB typing.Conclusion Gene HSP60 maybe a new multidrug resistant related gene.

关 键 词：白血病 耐药基因 HSP60 

分 类 号：R733.7[医药卫生—肿瘤]