谷胱甘肽转硫酶P1基因多态性及其与胃癌遗传易感性的关系  

Relationship between the polymorphism of GSTP1 and susceptibility to gastric cancer in Southwest Chinese

作　　者：邓少丽[1] 袁涛[1] 陈鸣[1] 黄恒柳[1] 夏季[1] 陈伟[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所检验科,重庆400042

出　　处：《中国现代医学杂志》2011年第1期73-74,78,共3页China Journal of Modern Medicine

基　　金：第三军医大学校临床科研课题基金(No:2008-1087)

摘　　要：目的为了分析中国西南地区人群谷胱甘肽转硫酶P1基因(GSTP1)的多态性分布,同时探讨GSTP1基因多态性与胃癌发病风险的关系。方法采用PCR-RFLP及基因测序法检测160例胃癌患者及130例正常人外周血GSTP1基因的Ile105Val多态性,进行胃癌风险分析。结果中国西南地区人群GSTP1基因Val等位基因的分布频率为18%,其中胃癌患者人群GSTP1基因Val等位基因分布频率为30%,正常人群Val等位基因分布频率为5%。结论 GSTP1基因Val等位基因的分布存在人群及地区差异,携带GSTP1基因Val等位基因的个体胃癌发病风险增高。[ Objective ] To analyze the distribution of glutathione-S-transferase P1 gene （GSTP1） polymorphism in a population from Southwest China, and evaluate the relationship between GSTP1 polymorphism and gastric cancer susceptibility. [Methods] Blood samples were taken from 160 gastric cancer patients and 130 control peoples. PCR and restriction fragment length polymorphism （RFLP） were performed to analyze the genotype of a GSTP1 poly- morphism in exon5 （ILE 105 Val）. [Results] GSTP1 Val variant allele frequency was 18% in population from Southwest of China. The Val allele frequency in gastric cancer patients was 30%. [ Conclusions ] The frequency of GSTP1 Val/Val genotype was statistically higher in the gastric cancer group compared to the non-gastric cancer population.

关 键 词：谷胱甘肽转硫酶 基因多态性 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]