色胺酮热特性分析  

Determination of tryptanthrin of thermal characteristic using thermal analysis

作　　者：刘毅[1] 黄海伟[1] 杨腊虎[1] 刘建利[2] 

机构地区：[1]中国食品药品检定研究院,北京100050 [2]西北大学生命科学院,陕西西安710069

出　　处：《中国医院药学杂志》2011年第3期201-203,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究色胺酮的热特性。方法:用差示扫描量热法观察了色胺酮的晶型情况;用热重法测量了色胺酮的热失重曲线,并用Kissinger法计算了其表观活化能;同时应用红外吸收光谱和X-射线衍射图谱进行了佐证。结果:色胺酮可能存在有多晶型现象,利用热失重法测得的表观活化能为83.28KJ.mol-1。结论:获得了色胺酮的热力学特征,为该化合物的应用进行了基础研究。OBJECTIVE To study the thermal property of tryptanthrin.METHODS The thermal property of tryptanthrin was investigated by using differential scanning calorimetry(DSC) and thermogravimetric analysis(TGA) in the temperature range of 50-300 ℃ and the different heating rate.The structure of tryptanthrin was characterized by fouriertransform infraared spectra(FTIR) and X-ray powder diffraction.RESULTS Tryptanthrin maybe a polymorphous material,and the activation energy was determined by TGA according to the Kissinger′s equation.CONCLUSION The thermal property of tryptanthrin obtained gives references for its preparation study.

关 键 词：色胺酮 差示扫描量热法 热重分析法 

分 类 号：R917[医药卫生—药物分析学]