半夏泻心汤辅治功能性消化不良42例  

Banxia Xiexin Decoction in Adjuvant Treatment of Functional Dyspepsia: A Report of 42 Cases

作　　者：谢晓玲[1] 张丽[1] 彭云[1] 

机构地区：[1]湖北省荆州市第二人民医院消化内科,湖北荆州434000

出　　处：《安徽中医学院学报》2011年第1期30-32,共3页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的观察半夏泻心汤辅助治疗功能性消化不良的临床疗效及其对血浆胃动素的影响。方法将82例确诊为功能性消化不良的患者随机分为治疗组42例和对照组40例,对照组按西医功能性消化不良治疗方案进行抑酸、清除幽门螺杆菌及使用胃动力药,必要时给予心理疏导及抗抑郁药治疗。治疗组在西医治疗基础上加用中药半夏泻心汤治疗,观察两组治疗4周后血浆胃动素水平及治疗前后临床症状改善情况。结果治疗4周后,治疗组总有效率为95.2%,对照组为77.5%,两组总有效率差异存在统计学意义(P<0.05);治疗组血浆胃动素水平显著高于对照组(P<0.05);治疗组在改善上腹痛、上腹饱胀、反酸、上腹烧灼感、嗳气、腹胀方面显著优于对照组(P<0.05)。结论半夏泻心汤通过提高功能性消化不良患者血浆胃动素水平而有效改善患者的胃肠功能障碍,从而改善患者的临床症状。Objective To observe the therapeutic effects of Banxia Xiexin Decoction,a representative traditional Chinese prescription for epigastric fullness and distension in the book of Treatise on Febrile Diseases,in adjuvant treatment of functional dyspepsia（FD） and its effect on plasma level of motilin（MTL）.Methods Eighty-two patients with FD were randomized into treatment group and control group.Forty patients in control group were treated with drugs for inhibiting the secretion of gastric acid,eliminating Helicobacter pylori,promoting gastric motility,and psychological counseling and antidepressive therapies if necessary,according to the therapeutic regimen for FD in western medicine.Additionally,forty-two patients in treatment group were treated with Banxia Xiexin Decoction on the basis of western medical therapies.Before treatment and four weeks after treatment,the levels of MTL,and the total effective rate as well as the improvement of main symptoms were observed and compared between the two groups.Results Four weeks after treatment,the total effective rate was 95.2% in treatment group,being significantly higher than 77.5% in control group.The plasma level of MTL in treatment group was significantly higher than that in control group.Treatment group was superior to control group in ameliorating epigastric pain,epigastric distension,epigastric burning sensation,belching,and abdominal distension.Conclusion Banxia Xiexin Decoction can ameliorate clinical symptoms in FD patients via increasing plasma level of MTL to regulate gastrointestinal dysfunction.

关 键 词：功能性消化不良 胃动素 半夏泻心汤 

分 类 号：R57[医药卫生—消化系统]