还原性谷胱甘肽治疗酒精性肝硬化60例临床观察  

Clinical Observation on 60 Cases Alcoholic Liver Cirrhosis Treated with reduced glutathione

作　　者：吴新员[1] 黎志良[1] 周伶俐[1] 黄佳[1] 

机构地区：[1]湖北省通城县人民医院,湖北通城437400

出　　处：《河北医学》2011年第1期61-63,共3页Hebei Medicine

摘　　要：目的:观察还原型谷胱甘肽治疗酒精性肝硬化的临床疗效。方法:120例酒精性肝硬化患者,随机等分为治疗组(60例)和对照组(60例)。对照组采用常规治疗,治疗组在此基础上给予还原型谷胱甘肽1.2g静脉滴注,每日1次,共治疗2wk。观察两组临床疗效并检测治疗前后肝功及肝纤维化指标的变化。结果:治疗组在改善患者症状、体征及降低肝功能、肝纤维化指标方面均明显优于对照组,两组差异有显著性意义(P<0.01)。结论:还原型谷胱甘肽对酒精性肝硬化有良好的治疗作用,可显著改善肝功能,抑制肝纤维化。Objective： To observe the therapeutic efficacy of reduced glutathione for patients with alcoholic cirrhosis.Method： One hundred and twenty patients with alcoholic cirrhosis were randomly divided into two groups.The control group received routine therapy alone,while the trial group received reduced glutathione injection（1.2g） q.d plus routine therapy for 2 weeks.Then observed the changes of symptoms and signs,hepatic function and hepatic fibrosis.Result： The improvement in symptoms and signs,the hepatic function and hepatic fibrosis in the trial group was significant superior to those in the control group,There＇s significant differences between the two groups（P0.01）.Conclusion： Reduced glutathione has remarkable therapeutic efficacy for patients with alcoholic cirrhosis,it can distinctly improve the hepatic functions and inhibit liver fibrosis.

关 键 词：还原型谷胱甘肽 酒精性肝硬化 肝纤维化 临床疗效 

分 类 号：R575.2[医药卫生—消化系统]