PSA-NCAM与大鼠海马区神经细胞的发生  

PSA-NCAM and neurogenesis in the rat hippocampus

作　　者：李忠[1] 

机构地区：[1]承德市中心医院,河北省承德市067000

出　　处：《中国组织工程研究与临床康复》2010年第45期8495-8498,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:已有大量动物实验表明在成熟动物的大脑存在神经细胞的可再生区域,海马齿状回产生的新生神经细胞可以迁移到颗粒层,分化为有功能的神经细胞。目的:通过对神经干细胞的特性及其分化、迁移及存活的影响因素的探讨,为脑损伤的治疗提供了新思路。方法:分别以"神经干细胞、PSA-NCAM、脑梗死","Neural stem cells、PSA-NCAM、Cerebral Infarction"为检索词,应用计算机检索CNKI期刊全文数据库及Pubmed数据库1996/2009有关文章。纳入PSA-NCAM与大鼠海马区神经细胞发生文献。排除与研究目的无关和内容重复者。保留48篇文献做进一步分析。结果与结论:目前大量研究表明在海马齿状回、侧脑室下区、嗅球等部位仍然存在神经再生能力,在这些部位存在大量神经干细胞,这些神经干细胞具有增殖分化再生的功能,中枢神经存在大量促进神经干细胞增殖、分化、迁移的细胞因子,其中PSA-NCAM为其中之一。BACKGROUND：Numerous animal studies have shown that the brain of mature animals contains regeneration field of neural cells.New neural cells produced by hippocampal dentate gyrus can migrate to the granular layer,and differentiate into functional neural cells.OBJECTIVE：To provide new ideas for the treatment of brain injury by studying the feature of neural stem cells and the affected factors of the new cells differentiation,migration and survival.METHODS：The computer was applied to retrieve the articles in CNKI periodical full-text database and PubMed database published from 1996 to 2009.Words for retrieve were ＂Neural stem cells,PSA-NCAM,cerebral infarction＂.Articles concerning PSA-NCAM and neurogenesis in the rat hippocampus were included.The literature of irrelevant purpose and repetitive content was excluded,and then 48 literatures were retained to summarize.RESULTS AND CONCLUSION：Neurogenesis continues in the hippocampal dentate gyrus,the subventricular zone of the lateral ventricle and olfactory bulb.These regions contain abundant neural stem cells,which have the ability of proliferation,differentiation and regeneration.The central nerve has many cytokines that can promote proliferation,differentiation and migration of neural stem cells,including PSA-NCAM.

关 键 词：神经干细胞 脑梗死 PSA-NCAM 组织工程 综述 

分 类 号：R394.2[医药卫生—医学遗传学]