Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin  

作　　者：Xia Ding Feng Yan Phil Yao Zhihong Yang Weihong Wan Xiwei Wang Jing Liu Xinjiao Gao Ariane Abrieu Tongge Zhu Jiancun Zhang Zhen Dou Xuebiao Yao 

机构地区：[1]Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, Hefei 230027, China [2]Georgia Cancer Coalition, Atlanta, GA 30310, USA [3]Beijing University of Chinese Medicine, Beijing 100026, China [4]Proteomics Research Laboratory, Beijing 100086, China [5]Universites Montpellier, 34293 Montpellier, France

出　　处：《Cell Research》2010年第12期1386-1389,共4页细胞研究（英文版）

基　　金：Acknowledgments We thank members of our groups for insightful discussion during the course of this study. This work was initiated by the chemical biology grant PGX-t from the Proteomics Research Laboratory, and supported in part by Chinese Academy of Sciences Grants （KSCX2-YW-H-10 and KSCX2-YW-R195）, 973 projects （2002CB713700; 2010CB912103）, National Natural Science Foundation of China （90913016）, and Georgia Cancer Coalition Eminent Scholar Award.

摘　　要：Dear Editor, Chromosome movements during mitosis are orches- trated primarily by the interaction of spindle microtu- bules with the kinetochore [1], the site for attachment of spindle microtubules to the centromere. The kinetochore has an active function in chromosomal segregation through microtubule-based motors located at or near it [1-2]. CENP-E is a microtubule-based kinesin motor [3],

关 键 词：染色体分离 着丝粒 抑制剂 小分子 有丝分裂 相互作用 驱动蛋白 微管 

分 类 号：Q343.2[生物学—遗传学] TD923.14[矿业工程—选矿]