Toll样受体在脑损伤中的作用机制和研究进展  

Action mechanisms of Toll-like receptors in brain injury

作　　者：李光照[1] 杭春华[1] 

机构地区：[1]南方医科大学南京临床医学院(南京军区南京总医院)神经外科,南京210002

出　　处：《医学研究生学报》2010年第12期1319-1323,共5页Journal of Medical Postgraduates

基　　金：南京军区医学科学技术研究"十一五"计划课题(06MA125)

摘　　要：Toll样受体(Toll-like receptor,TLR)参与宿主抵抗外界致病微生物入侵机体的第一道防线,在非感染性疾病中与体内相应的内源性配体结合可触发免疫炎性反应。在中枢神经系统疾病中,免疫炎症反应对脑组织有重要的损害作用。TLR在中枢神经系统内广泛表达,脑损伤后各种内源性配体释放,可与TLR结合,通过信号级联传导,参与脑损伤的病理生理过程。Toll-like receptors（TLR） constitute the first-line defense of the body against the invasion of external pathogenic microorganisms and,when combined with the corresponding endogenous ligand in non-infectious disease in vivo,can trigger the immune inflammatory response.In central nervous system diseases,immune and inflammatory responses inflict serious damage on the brain tissue.TLRs are extensively expressed in the central nervous system.Brain injury induces the release of various endogenous ligands,which are combined with TLRs via the signal transduction cascade and involved in the pathophysiological process of brain injury.

关 键 词：TOLL样受体 TLR4 TLR2 脑损伤 

分 类 号：R742[医药卫生—神经病学与精神病学]