RADIL基因在胰腺癌组织中的表达及其临床意义  

Expression and clinical implications of RADIL gene in pancreatic cancer

作　　者：黄浩杰[1] 高军[1] 杜奕奇[1] 龚燕芳[1] 吕顺莉[1] 王小玮[1] 许爱平[1] 高飞[1,2] 李兆申[1] 

机构地区：[1]第二军医大学长海医院消化内科,上海200433 [2]沈阳军区总医院内窥镜科

出　　处：《中华胰腺病杂志》2010年第6期424-426,共3页Chinese Journal of Pancreatology

摘　　要：目的 探讨胰腺癌组织中RADIL基因的表达及其与临床病理特征之间的相关性.方法 采用实时定量PCR方法检测40例胰腺癌及相应癌旁组织和5例正常胰腺组织中RADIL mRNA相对表达量,分析RADIL mRNA表达与胰腺癌临床病理特征之间的相关性.结果 RADIL mRNA在胰腺癌组织、癌旁组织及正常胰腺组织中均有表达,相对表达量分别为2.263±3.826、5.425±8.858和8.559±4.214,三组之间存在显著差异（P＜0.05）.癌组织中RADIL mRNA高表达与肿瘤远处转移、分化程度呈负相关（r为-0.312和-0.294,P值均＜0.05）,与肿瘤部位、肿瘤大小,血清CA19-9浓度、TNM分期及患者的性别和年龄均无显著相关性.结论 RADIL基因对胰腺癌可能具有一定的抑制作用.Objective To investigate the RADIL mRNA expression in pancreatic carcinoma and to evaluate its clinical significance.Methods Fluoesecent quantitative PCR （FQ-PCR） was used to detect the RADIL mRNA expression in 40 patients with pancreatic carcinoma and adjacent tissue and in 5 healthy adult with normal pancreatic tissue and to observe its relationship with clinicopathologic parameters.Results RADIL mRNA was expressed in pancreatic carcinoma and adjacent tissue, as well as normal pancreatic tissue, and the relative expression was 2.263 ± 3.826, 5.425 ± 8.858 and 8.559 ± 4.214, respectively.There was statistically significant difference among the three groups （P 〈0.05 ）.RADIL mRNA expression was closely related with the metastasis and differentiation grade （ r = -0.312 and -0.294, P 〈 0.05 ）, however, it was not significantly related to tumor site, tumor size, CA19-9, TNM staging, sex and age.Conclusions RADIL gene may have an inhibitory effect on the pancreatic cancer.

关 键 词：胰腺肿瘤 小GTP结合蛋白质类 实时荧光定量聚合酶链式反应 RADIL基因 

分 类 号：R735.9[医药卫生—肿瘤]