蓝莓对D-半乳糖模型小鼠学习记忆及抗氧化的研究  

The study on memory and antioxidantion of blueberry to the D-galactose model of mouse

作　　者：赵君操[1] 

机构地区：[1]河南省肿瘤医院药剂科,河南郑州450008

出　　处：《河南医学研究》2010年第4期401-403,共3页Henan Medical Research

摘　　要：目的:探讨蓝莓对D-半乳糖致衰老小鼠学习记忆能力及抗氧化作用的影响。方法:连续给小鼠注射D-半乳糖6周,同时从第3周起给模型鼠灌胃蓝莓,给药结束后,进行学习记忆行为测定,采血清测定超氧化歧化酶(SOD),丙二醛(MDA)含量。结果:蓝莓组小鼠的学习、记忆获得和记忆消退的错误次数明显少于衰老模型组(P<0.05);与模型组比较,蓝莓组小鼠血清SOD活性显著性降低。结论:蓝莓能改善D-半乳糖致衰老小鼠的学习记忆能力,提高体内SOD活性,增强其对自由基的清除能力,抑制脂质过氧化作用。Objective： To study the learning memory and antioxidantion of blueberry to the model of mouse aging with the inducement of D-galactose.Methods： The mouse injected D-galactose 6 weeks,while the third week the mouse of Blueberry model group were given blueberry,after 6 weeks,the effects of blueberry on learning and memory were evaluated and MDA and SOD activity in serum of aging mouse were measured.Results： Compared with the model group black currant extracts group＇s learning,memory access and faded memory error significantly less than the number of aging model group（P0.05）,and serum SOD activity significantly lower.Conclusion： blueberry can improve the learning and memory of aging mouse,raising SOD activity in the body,enhance its ability to remove free radicals and inhibiting lipid peroxidation.

关 键 词：蓝莓 D-半乳糖 学习记忆 抗氧化 

分 类 号：R-332[医药卫生]