血清HA、PCⅢ、CⅣ及LN的水平在肝纤维化与早期肝硬化中的意义  

The significance of serum levels of hyaluronic acid,type Ⅲ procollagen, type Ⅳ collagen and laminin in liver fibrosis and early cirrhosis

作　　者：张怀宏[1] 翟玉峰[1] 段钟平[2] 高岩[1] 

机构地区：[1]河南省南阳市中心医院,473009 [2]北京友谊医院肝病中心,100050

出　　处：《胃肠病学和肝病学杂志》1999年第3期194-196,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　通过检测血清透明质酸（ＨＡ） 、Ⅲ型前胶原（ＰＣⅢ） 、Ⅳ型胶原（ＣⅣ） 及层粘素（ＬＮ） 的水平，了解该四项血清指标与肝纤维化及早期肝硬化的关系。方法　３６ 例慢性乙型肝炎（ 慢乙肝） 患者的血清ＨＡ、ＰＣⅢ及ＬＮ 用放免法检测（ ＲＩＡ） ；ＣⅣ用酶免法检测（ＥＩＡ） ，并与肝穿病理炎症分级（Ｇ） 和纤维化分期（Ｓ） 进行比较。结果　血清中ＨＡ、ＰＣⅢ、ＣⅣ及ＬＮ 水平与肝纤维化及早期肝硬化关系密切（ Ｐ＜ ０－０５ － ０－０１） 。结论　血清中ＨＡ、ＰＣⅢ、ＣⅣ及ＬＮ 均为较好反映肝纤维化及早期肝硬化的指标。其中ＨＡ 价值最大。Aim To study on relation of serum levels of hyaluronic acid(HA),type Ⅲ procollagen (PCⅢ),type IV collagen (CⅣ)and laminin (LN) in liver fibrosis and early cirrhosis.Methods Serum markers of HA、PCⅢ and LN were measured with RIA,CⅣ was measured with EIA and liver biopsies were carried out in 36 cases with chronic hepatitis B.Serum levels of HA,PCⅢ,CⅣ and LN were analysed,then compared to histological findings described by Scheuer.Results Serum levels of HA,PCⅢ,CⅣ and LN significantly correlated with liver inflammation activity and fibrosis (P<0 05-0 01).Conclusion Serum levels of HA,PCⅢ.CⅣ and LN were strongly correlated with degree of liver fibrosis.HA was more sensitive and specific than others.PCⅢ tended to represent active hepatic fibrogenesis.

关 键 词：透明质酸 胶原 层粘素 肝纤维化 早期 肝硬化 

分 类 号：R575.202[医药卫生—消化系统]