阿司匹林预防失败脑梗死患者的影响因素分析  

Analysis on the influencing factors of cerebral infarction patients with aspirin prevention failure

作　　者：茅新蕾[1] 韩丽雅[1] 黄向东[1] 管朝红[1] 颜雪琴[2] 陈卫东[2] 

机构地区：[1]温州市第二人民医院神经内科 [2]温州医学院附属第二医院神经内科

出　　处：《中国临床药理学与治疗学》2010年第10期1148-1151,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省医药卫生科学研究基金(2006A107)

摘　　要：目的:探讨阿司匹林预防失败脑梗死患者的影响因素。方法:收集139例阿司匹林预防失败的脑梗死患者及24例长期规律服用阿司匹林的社区体检者,采集病史,检测身高、体重、血糖、血脂、血常规等指标,其中60例无心房颤动脑梗死患者及24例社区体检者检测尿11-去氢-血栓素B2(11-DH-TXB2)浓度。比较两组间各临床因素。结果:与对照组相比,阿司匹林预防失败脑梗死患者男性、吸烟、既往脑梗死病史、心房颤动比例、尿11-DH-TXB2浓度显著升高,高密度脂蛋白胆固醇(HDL-C)明显降低。Logistic回归显示既往脑梗死病史、尿11-DH-TXB2浓度与阿司匹林预防失败密切相关。结论:男性、吸烟、既往脑梗死病史、心房颤动、HDL-C降低与阿司匹林预防失败有关,阿司匹林抵抗是阿司匹林预防失败的一个重要危险因素。AIM：To investigate the influencing factors of cerebral infarction patients with aspirin prevention failure.METHODS：139 cerebral infarction patients with aspirin prevention failure and 24 community health examination cases who were regularly administered aspirin for long-term,were enrolled in the study.Everybody＇s medical history was recorded.Medical examinations included the measurement of weight,height,fasting blood lipid,glucose concentrations,and blood routine.The concentration of urinary 11-dehydrothromboxane B2 of 60 patients without atrial fibrillation and 24 community health examination cases were determined.The clinical influencing factors of patients with aspirin prevention failure were compared with the controls.RESULTS：As compared with the controls,there were statistically significant differences in percentage of male,smoking,previous cerebral infarction,atrial fibrillation,high-density lipoprotein cholesterol concentrations and urinary 11-dehydrothromboxane B2 concentrations（P0.05）.The results of logistic regression showed that there were significant correlation between aspirin failures and previous cerebral infarction,urine 11-DH-TXB2 concentrations.CONCLUSION：It is suggested that male,smoking,previous cerebral infarction,atrial fibrillation,low high-density lipoprotein cholesterol are risk factors of aspirin failures.Aspirin resistance is an important risk factor for aspirin failures.

关 键 词：脑梗死 阿司匹林 阿司匹林抵抗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]