CDX2基因与白血病关系的研究进展  

A review on the gene of the caudal-type homeobox gene -2 in leukemia

作　　者：李迎侠(综述)[1] 潘凯丽(审校)[1] 钱新宏(审校)[1] 

机构地区：[1]第四军医大学西京医院儿科,西安710032

出　　处：《国际儿科学杂志》2011年第1期85-88,共4页International Journal of Pediatrics

基　　金：陕西省科学技术研究发展计划项目（2009k12-02）

摘　　要：尾型同源盒基因（CDX）家族成员CDX2基因是促进胚胎发育和参与造血调控的主控基因.新近研究发现,CDX2在各型白血病中异常表达,是与白血病发生、发展和颅后相关的新的致白血病基因,可望成为白血病微小残留病检测的泛基因标志.CDX2通过调节HOX基因参与白血病转化,进一步探讨CDX2的致白血病机制及其与白血病的关系,对预测白血病复发及个体化、靶向治疗意义重大.The gene of the caudal-type homeobox gene -2 （ CDX2）, a member of the CDX family, is a principal regulator in the development of embryogenesis and haematogenesis . Recent studies have shown aberrant expression of CDX2 in each subtype of leukemia and its involvement in the genesis, progress and prognosis of leukemia as new gene. CDX2 may be a potential gene maker of leukemia in minimal residual disease detection.Studies also suggested that CDX2 be involved in leukemia by modulating HOX gene. To further investigate the mechanism of CDX2 in leukemia can be of great significance for the prediction of relapse and the individualized and targeted therapy.

关 键 词：尾型同源盒基因-2 白血病 同源盒基因 微小残留病 

分 类 号：R733.702[医药卫生—肿瘤]