益生菌在维持治疗溃疡性结肠炎中的疗效观察  

Effects of Probiotics as Maintenance Therapy in Ulcerative Colitis

作　　者：胡桂梅[1] 秦丽君[1] 郑拓[1] 

机构地区：[1]浙江省宁波大学医学院附属医院消化科,宁波315020

出　　处：《浙江中西医结合杂志》2011年第1期7-9,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨益生菌在溃疡性结肠炎维持治疗中的作用。方法:将58例溃疡性结肠炎缓解期患者随机分为观察组(益生菌联合美沙拉嗪)和对照组(美沙拉嗪),观察两组溃疡性结肠炎复发率及在0、6、12个月疾病活动指数、内镜和病理评分。结果:两组在0、6、12个月溃疡性结肠炎复发率、Sourtherland疾病活动指数、内镜和病理评分比较均无明显统计学意义,P>0.05。结论:益生菌作为溃疡性结肠炎维持治疗与美沙拉嗪在临床随访1年中具有相同的预防复发的效果,合并使用益生菌和美沙拉嗪作为溃疡性结肠炎维持治疗是没有必要的。Objective： To evaluate the efficacy of probiotics as maintenance treatment in ulcerative colitis.Methods： A total of 58 ulcerative colitis patients with remission were randomized to receive probiotics plus mesalazine（29 patients） and mesalazine（29 patients）.Disease activity index and endoscopic and histological scores were calculated in both groups in 0,6,and 12 months and relapse was recorded.Results： No significant difference in relapse rate in 6（P=0.666） and 12 months（P=0.345） was noted between the 2 groups and the same result was found in disease activity index and endoscopic and histological scores in 0,6,and 12 months（P0.05）.Conclusions： Mesalazin plus probiotics as maintenance treatment in ulcerative colitis has the same effect as mesalazine alone on maintaining remission of ulcerative colitis in the 1st year.It is unnecessary to use probiotics and mesalazine together as maintenance treatment in ulcerative colitis.

关 键 词：溃疡性结肠炎 益生菌 维持治疗 

分 类 号：R574.62[医药卫生—消化系统]