视网膜母细胞瘤109例分析  

Analysis of 109 cases of retinablastoma

作　　者：龙心光[1] 王映芬[1] 

机构地区：[1]广东医学院附属医院眼科,湛江524001

出　　处：《广东医学院学报》1999年第3期222-223,共2页Journal of Guangdong Medical College

摘　　要：目的：分析视网膜母细胞瘤（ Ｒ Ｂ）的发病特点和诊治规律。方法：收集本院近２３ ａ 来的１０９ 例 Ｒ Ｂ病例，对其临床特点、病理表现、治疗、预后及家系调查作一回顾性分析。结果：７７．１％ 的病例就诊年龄小于５ 岁。２２ 例（２０．２％ ）为双眼发病，９ 例（８．３％ ）具有肿瘤家族史。１０９ 例中以晚期患者最多见，病理检查大多可见有视神经和巩膜浸润。治疗以眼球摘除术为主，一些病例辅以放疗，预后不佳。家系调查发现除 Ｒ Ｂ外，尚可见其它恶性肿瘤。结论： Ｒ Ｂ仍是儿童最常见的眼内恶性肿瘤，对于晚期患者眼球摘除术仍是治疗的主要方法。病理诊断对于选择治疗方法更有帮助。强调早期诊治的重要性和必要性，尤其对有肿瘤家族史的小儿应行早期眼底全面检查。Objective:To study the clinical features and treatment of retinoblastoma (RB). Methods:The clinical features,pathological findings,family history,treatment and prognosis were retrospectively analyzed in 109 RB cases from 1972 to 1995.Results:Most diagnosed cases(77.1%) were under 5 years,20.2% were bilateral,nine cases(8.3%)had family tumor history.Most of the cases were clinically in the late stage,whose optic nerves or sclera were pathologically invaded.In treatment,enucleation was still the first choice for these cases.Supplementary radiotherapy was used in some cases with a poor prognosis.Some other tumors had been found in their relatives on the family investigation.Conclusions:RB is the most common intra ocular tumor in children.The enucleation is still the choice of treatment for cases in the late stage.The importance of the pathological diagnosis was emphasized on the choice of treatment methods.Early diagnosis and treatment is the key to increase the survival rate.A thorough fundus examination is important espeacially for these children who have family tumor history.

关 键 词：视网膜母细胞瘤 临床 治疗 家系 

分 类 号：R739.72[医药卫生—肿瘤]