GSTM1基因多态性与食管癌遗传易感性的关系  

Relationship between the GSTM1 Genetic Polymorphism and Susceptibility to Squamous Cell Carcinoma of Esophagus

作　　者：邵根泽[1] 胡智[1] 李恩民[1] 李璟[1] 温博贵[1] 

机构地区：[1]汕头大学医学院生化教研室,汕头515031

出　　处：《汕头大学医学院学报》1999年第3期1-3,共3页Journal of Shantou University Medical College

摘　　要：目的 :探讨GSTM1基因多态性与食管癌遗传易感性的可能关系。方法 :采用PCR法对正常人和食管癌患者基因组DNA进行GSTM1基因分型。结果 :1 0 8例食管癌患者中 68例为GSTM1 ( / )型 ;1 1 2例正常对照组标本中 5 5例为GSTM1 ( / )型。 2组人群GSTM1基因缺失率存在显著性差异 (P <0 0 5 )。结论 :GSTM1基因多态性与食管癌易感性相关 ,GSTM1 ( / )Objective:To investigate the relationship between genetic polymorphisms of glutathione S_transferase M1(GSTM1) and susceptibility to squamous cell carcinoma of esophagus.Method:The polymerase chain reaction(PCR) was used to the GSTM1 genotypes between the normals and the patients with esophageal cancer.Result:68 of 108 patients with esophageal cancer,and 55 of 112 normals were all GSTM1 nullification,but the rate of that in two groups had significant difference( P <0 05).Conclusion:There is a relationship between GSTM1 genetic polymorphisms and susceptibility to esophageal cancer,individuals with GSTM1 nullification had an increased risk of developing esophageal cancer.

关 键 词：鳞状细胞癌 基因多态性 食管肿瘤 遗传易感性 

分 类 号：R735.102[医药卫生—肿瘤]