咪唑型离子液体对小鼠的急性毒性  

Acute toxicity of imidazolium ionic liquid to mice

作　　者：徐红梅[1,2] 田芳[1] 靳丹萍[2] 丁运生[2] 张威[1] 严国林[1] 杨珍[1] 卓彩虹[1] 

机构地区：[1]合肥工业大学化工学院制药工程系,合肥230009 [2]合肥工业大学化工学院高分子材料与化工研究所,合肥230009

出　　处：《环境科学学报》2011年第2期420-423,共4页Acta Scientiae Circumstantiae

基　　金：国家自然科学基金项目(No.50973025);安徽省自然科学基金项目(No.090414180);安徽高校省级自然科学研究重点项目(No.KJ2009A019;KJ2010A263)~~

摘　　要：采用寇氏改良法研究了咪唑型离子液体对小鼠的急性毒性,并考察了烷基侧链长度对其毒性的影响,同时采用HE染色法观察了其对小鼠肝脏的毒性.结果表明,4种咪唑型离子液体([C10mim]Br、[C12mim]Br、[C14mim]Br和[C18mim]Br)对小鼠肝脏均有损伤,其LD50值在98.91～220.16mg·kg-1之间,为中等毒性.咪唑型离子液体对小鼠的急性毒性与其侧链长度有关,当碳链长度为14时,其毒性最强.The acute toxicity to mice of imidazolium ionic liquids （ILs） with varying alkyl chain lengths was evaluated by Karber＇s modified method and hepatic lesions were observed by hematoxylin-eosin staining. The results showed that four types of ILs including [C10mim]Br,[C12mim]Br,[C14mim]Br and [C18mim]Br produced obvious hepatic lesions in mice,and the LD50 of the ILs ranged from 98.91 to 220.16 mg·kg^-1,indicating a medium toxicity. The acute toxicity of different ILs to mice was related to the length of its side chain,and the strongest toxicity was observed for the ILs with the alkyl chain length of fourteen.

关 键 词：离子液体 急性毒性 半数致死量(LD50) 

分 类 号：X171.5[环境科学与工程—环境科学]