人类副流感病毒F蛋白抗原性的信息学分析  

Information Analysis of Antigenicity of F Protein of Human Parainfluenza Viruse

作　　者：苏喜荣[1] 李振梅[1] 

机构地区：[1]山东技师学院,济南250200

出　　处：《价值工程》2011年第5期223-224,共2页Value Engineering

摘　　要：依据报道的人类副流感病毒I型F蛋白氨基酸序列,通过SPOMA服务器、Signalp3.0服务器预测了F蛋白的二级结构和信号肽;通过TMHMM-2.0服务器预测了F蛋白的跨膜区;通过使用PROTSCALE服务器、SYFPEITHI服务器和Harvard的工具,综合分析得出F蛋白上第190-195和390-399区段可能为抗原肽段区域。该研究结果为副流感亚单位疫苗的研制奠定了基础。According to the sequence of human parainfluenza viruses F protein from NCBI,the secondary structure and the signal peptide were predicted by the methods of SOPMA and Signalp3.0.The transmembrane domain was predicted by the method of TMHMM-2.0.Moreover,the antigen domains of F protein possibly localized in the regions of 190-195 and 390-399 by the methods of PROTSCALE、SYFPEITHI and Harvard.These results are helpful for the research of human parainfluenza viruses vaccine.

关 键 词：人类副流感病毒 F蛋白 抗原性 信息学分析 

分 类 号：R-3[医药卫生]