肺癌微转移相关标记物及其检测  

Biomarkers of lung cancer micro-metastasis and their detection

作　　者：马靓[1] 茅国新[1] 

机构地区：[1]江苏省南通大学附属医院肿瘤化疗科,南通226001

出　　处：《国际肿瘤学杂志》2011年第1期39-42,共4页Journal of International Oncology

摘　　要：肺癌微转移是肿瘤在细胞和分子水平上的微量转移。研究发现，通过某些肿瘤标记物的早期检测，可提高TNM分期的准确性，了解肺癌患者预后，正确选择治疗方案。目前发现的特异性和敏感性较好的标记物，包括细胞角蛋白19mRNA、肺特异性X蛋白mRNA、黏蛋白基因1、胃泌素释放肽受体mRNA等。检测方法有逆转录聚合酶链反应、免疫组化、蛋白印迹法等。Micrometastasis is small metastasis at the cellular and molecular level. Early detection of micrometasis through tumor markers can improve the accuracy of TNM staging, prognosis and subsequently treatment for lung cancer patients. Currently, a number of markers with good specificity and sensitivity have been found, including CK19 mRNA, Lunx mRNA, MUC1 mRNA and GPRP mRNA. These markers can be detected using methods such as RT-PCR, immunohistochemistry and western blot.

关 键 词：肺肿瘤 微转移 肿瘤标记 生物学 

分 类 号：R734.2[医药卫生—肿瘤]