裸鼠模型在人膀胱癌中的实验研究现状及展望  

Status and prospects of application of nude mouse models in research of human bladder tumor

作　　者：朱德淳[1] 刘禄成[1] 温都苏[1] 

机构地区：[1]吉林大学第二医院泌尿外科,长春130041

出　　处：《国际肿瘤学杂志》2011年第1期70-73,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30972981）

摘　　要：人源性膀胱癌裸鼠模型与人类膀胱癌生长特性相似，能更好地模拟膀胱癌在人体内的自然生长过程及许多生物学行为。为深入研究人膀胱癌发生发展与转归机制，进行新型膀胱腔内生物免疫制剂和化疗药物临床前期评价，探索分子靶向治疗策略，建立人源性膀胱癌裸鼠模型具有重要的临床与科研意义。Nude mouse bearing human bladder cancer exhibits similar growth characteristics as human bladder cancer and therfore is a good simulation model in the research of the biological behaviors of human bladder cancer. To explore the initiation, development, prognosis and biological behavior of human bladder cancer, and to develop intravesical biological agents and antitumor drugs with improved strategies for prevention and treatment of bladder cancer, it is essential to establish human bladder tumor-beating nude mice for basic and clinical researches. This is a review of the current status of the application of human bladder tumor-bearing nude mice.

关 键 词：膀胱肿瘤 疾病模型 动物 

分 类 号：R737.14[医药卫生—肿瘤]