氙CT对缺血性脑血管病血管储备功能的研究  

Evaluation of cerebrovascular reserve by xenon computed tomography in patients with ischemic stroke

作　　者：曹文杰[1] 董强[1] 

机构地区：[1]复旦大学附属华山医院神经内科,上海200040

出　　处：《中华内科杂志》2011年第1期32-35,共4页Chinese Journal of Internal Medicine

摘　　要：目的 评价合并有脑血管狭窄的缺血性脑血管病患者脑血管储备功能（CVR）的特点.方法 对20例有脑血管狭窄的缺血性脑血管病患者分别在静息状态和静脉注入乙酰唑胺（ACZ）后行氙CT脑血流灌注检查,定量测定ACZ负荷前后局部脑血流（rCBF）,计算CVR.比较所有受试全脑、患侧与健侧大脑半球、责任血管供应区与健侧对应血管供应区的rCBF和CVR.结果 责任血管供应区与健侧对应区域rCBF和CVR：两者静息rCBF差异无统计学意义,责任血骨供应区CVR低于健侧对应区域[（5.9±24.3）%比（25.9±32.6）%,P＜0.05].结论 CVR下降是合并有脑血管狭窄缺血性卒中患者的重要特点.Objective To evaluate the cerebrovascular reserve（CVR） in patients of ischemic stroke with cerebrovascular stenosis by Xenon-enhanced CT. Methods Twenty subjects of ischemic stroke with cerebrovascular stenosis were recruited. All subjects were examined by Xenon-enhanced CT before and after acetazolamide （ACZ） challenge test to quantitatively measure the regional cerebral blood flow （rCBF） and CVR. Results We compared the rCBF in the corresponding region supplied with stenosed artery （divided manually） with that in the region of normal side. There was no significant difference in resting rCBF but in CVR [ipsilateral side vs. normal side （ 5.9 ± 24. 3 ） % vs （ 25.9 ± 32. 6 ） % , P 〈 0. 05]. Conclusion Impaired CVR is an important character of the patients with cerebrovascular stenosis suffered from ischemic stroke.

关 键 词：脑血管障碍 局部血流 氙CT 

分 类 号：R743.3[医药卫生—神经病学与精神病学]