鼻咽癌组织中HIF-2α和Caspase-3的表达及意义  

Expression and Significance of HIF-2α and Caspase-3 in Nasopharyngeal Carcinoma

作　　者：丁晖[1] 李先明[2] 高艳[2] 胡丽霞[1] 杨东[2] 周亚燕[2] 徐钢[2] 

机构地区：[1]暨南大学第二临床学院放射科,广东深圳518020 [2]暨南大学第二临床学院肿瘤放疗科,广东深圳518020

出　　处：《肿瘤防治研究》2011年第1期41-44,共4页Cancer Research on Prevention and Treatment

基　　金：广东省深圳市科技计划项目资金资助项目(200702102)

摘　　要：目的探讨乏氧诱导因子-2α(HIF-2α)和半胱氨酸天门冬氨酸蛋白酶-3(Caspase-3)在鼻咽癌组织中的表达及临床意义。方法应用免疫组织化学法检测46例初诊鼻咽癌组织和20例鼻咽慢性炎组织中HIF-2α和Caspase-3蛋白的表达。结果 HIF-2α蛋白在鼻咽癌组织中的表达高于鼻咽慢性炎性组织,而Caspase-3蛋白表达则相反(P<0.05);HIF-2α蛋白表达与患者性别、年龄、颈部淋巴结转移状态及临床分期无明显相关(P>0.05),与T分期的早晚相关(P<0.05)。Caspase-3蛋白的表达与患者的性别、年龄、T分期、颈部淋巴结转移状态及临床分期无明显相关(P>0.05)。鼻咽癌组织中HIF-2α和Caspase-3蛋白的阳性表达无相关性(r=-0.195,P>0.05)。结论 HIF-2α和Caspase-3蛋白的异常表达可能涉及鼻咽癌的发生和发展过程;HIF-2α蛋白的高表达可能与鼻咽癌恶性进展密切相关。Objective To explore the expression and clinical significance of HIF-2α and Caspase-3 in nasopharyngeal carcinoma（NPC）.Methods The expression of HIF-2α and Caspase-3 protein were examined by immunochemistry in 46 samples of NPC and 20 samples of chronic nasopharynxitis.ResultsThe expression of HIF-2α protein in NPC was higher than that in chronic nasopharynxitis while Caspase-3 protein was opposite（P0.05）.No statistical significance were observed between the expression of HIF-2α protein and patients gender,age,clinical staging and lymph node metastasis（P0.05）.There were significant statistical correlations between overexpression of HIF-2α protein and T stage.The expression of Caspase-3 was not significantly correlated with patients gender,age,T stage,clinical staging,and lymph node metastasis（P0.05）.There was no correlation between the expression of HIF-2α protein and Caspase-3 protein expression in NPC（r=-0.195,P0.05）.Conclusion The anomalous expression of HIF-2α and Caspase-3 may be associated with the carcinogenesis and development of NPC.There was significant correlation between the higher expression of HIF-2α protein and the malignant progression of NPC.

关 键 词：鼻咽肿瘤 HIF-2α CASPASE-3 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤]