广西新发现两个肝癌高发家族的病因学比较  

Comparative Analysis of Aetiology Clustering of Hepatocellular Carcinoma between Two Families with High Mortality of Hepatocellular Carcinoma Discovered Recently in Guangxi Region

作　　者：臧宁[1] 吴继周[2] 陈务卿[2] 吴健林[2] 宁秋悦[2] 邓一鸣[2] 韦颖华[2] 胡蝶飞[2] 李兰兰[2] 黄爱春[2] 罗双艳[2] 贺荣[2] 

机构地区：[1]广西医科大学实验中心,南宁530021 [2]广西医科大学第一附属医院感染性疾病科

出　　处：《肿瘤防治研究》2011年第1期101-103,共3页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金资助项目(30960170);广西卫生厅重点科研资助项目(桂卫重200849)

摘　　要：目的阐明在广西瑶族地区新发现的两个肝癌高发家族发生肝癌家族聚集性的危险因素。方法以广西瑶族不同地区的两肝癌高发家族成员作为研究对象,应用ELISA法检测研究对象血清中HBV和HCV血清学标志物、采用PCR和RT-PCR技术分别检测HBV DNA和HCV RNA,结合流行病学调查结果进行综合分析。结果两肝癌高发家族成员中HBsAg、HBsAb、HBeAg、HBeAb、HBcAb、HBVDNA、抗-HCV、HCVRNA的阳性率分别为45.0%(9/20)、35.0%(7/20)、15.0%(3/20)、25.0%(5/20)、45.0%(9/20)、25.0%(5/20)、0(0/20)、0(0/20)和9.52%(2/21)、42.9%(9/21)、4.8%(1/21)、4.8%(1/21)、23.8%(5/21)、9.52%(2/21)、0(0/21)、0(0/21)。其中HBsAg在两组间的差别具有统计学意义(P=0.033),A家族以山泉水作为饮用水,B家族十年前以塘水作为生活用水;其余因素差异未见统计学意义。结论瑶族不同地区、不同家族成员发生肝癌家族聚集性的危险因素可以有所不同,HBV感染、饮用塘水等因素均可与遗传因素相互作用,从而导致肝癌家族聚集性的发生。Objective To elucidate the risk factors in the development clustering of hepatocellular carcinoma in the two families in the area with high mortality of hepatocellular carcinoma in the minority of Yaos in Guangxi region.Methods The two families with clustering of hepatocellular carcinoma were from two different areas with high mortality of hepatocellular carcinoma in the minority of Yaos.Marks of HBV and HCV in sera were tested with ELISA.The HBVDNA and HCVRNA were measured with PCR and RT-PCR,respcetively.The data were analysed by combing with epidemiology survey.Results The positive rates of HBsAg,HBsAb,HBeAg,HBeAb,HBcAb,HBVDNA,anti-HCV and HCVRNA in the two families were 45.0%（9/20）,35.0%（7/20）,15.0%（3/20）,25.0%（5/20）,45.0%（9/20）,25.0%（5/20）,0.0%（0/20） and 0.0%（0/20） and 9.52%（2/21）,42.9%（9/21）,4.8%（1/21）,4.8%（1/21） 23.8%（5/21）,9.52%（2/21）,0.0%（0/21） and 0.0%（0/21） respectively.There was significant difference between the two families in the positive rate of HBsAg（P=0.01）.No significant difference was observed between two families in the positive rate of the other hepatitis virus serological marks.Familiy A used mountain water as the living water,while familiy B used pond water as the living water ten years before.Conclusion There might be a little difference of the risk factors for causation clustering of hepatocellular carcinoma in different area and in different family members.Infection of hepatitis B virus and pond water drinking interacted with the genetic factors,which could be the causation for the clustering of hepatocellular carcinoma.

关 键 词：原发性肝癌 家族聚集性 遗传因素 乙型肝炎病毒 丙型肝炎病毒 

分 类 号：R735.7[医药卫生—肿瘤] R512.62[医药卫生—临床医学]