慢性牙周炎与口腔幽门螺杆菌的相关性研究  

Correlativity of the chronic periodontitis with helicobacter pylori infection.

作　　者：高静[1] 朱声荣[1] 刘贤[2] 李月秀[3] 王艳春[3] 

机构地区：[1]华中科技大学同济医学院附属同济医院口腔医学中心,湖北武汉430030 [2]青岛大学医学院附属医院神经内科,山东青岛266003 [3]泰安市中心医院口腔科,山东泰安271000

出　　处：《临床口腔医学杂志》2011年第1期5-7,共3页Journal of Clinical Stomatology

基　　金：泰安市科技局资助项目(泰科计字[2002]9号)

摘　　要：目的:探讨慢性牙周炎患者与其口腔中的幽门螺杆菌(helicobacter pylori,HP)的相关性。方法:依据HP特异的尿素酶C和cagA基因设计引物,建立PCR方法。检测37例牙周炎患者口腔菌斑和含漱液中的HP,同时设立牙周健康对照组,比较两组的检测结果。结果:尿素酶C基因在牙周炎组的阳性率为64.8%,健康组为38.5%;尿素酶C基因和cagA基因共同阳性率在牙周炎组为32.4%,健康组为7.7%;两组差异有统计学意义;且轻型牙周炎患者口腔HP阳性率低于中、重型患者。龈下菌班HP阳性率高于龈上菌斑。结论:HP参与了慢性牙周炎的致病过程,抑或是加强了其它因素的致病过程,HP与牙周炎有相关性。Objective：To investigate the relationship between Helicobacter pylori（Hp） and periodontitis.Method：A polymerase chain reaction（PCR） assay with oligonucleotide primers homologous to a portion of the u-rease C and cytotoxin-associated gene A（cagA） ofHpwas used to test for the presence ofHpin dental plaque.Thirty-seven patients with periodontitis and 38 healthy persons were studied to compare the results of the two Groups.Result：In the periodontitis group,64.8 % f the tested samples was ureasc gene positive,and 32.4 % was positive for both urease C and cagA genes.In healthy persons,38.5 % of the tested samples was urease C gene posi-tive and 7.7 % was positive for both urease C and cagA genes.There was a significantly difference between the twogroups（P 0.01）.The Hp-positive rate of the major periodontitis was enhanced obviously to minor peciodontitis.The Hp-positive rate of subgingival plaque was significantly higher than that of supragingival plague.Conclusion：HP participates the formation of the chronic periodontitis or it increases the pathogenic effect of other factors.

关 键 词：幽门螺杆菌 聚合酶链反应 牙周炎 

分 类 号：R781.4[医药卫生—口腔医学]