慢性移植物抗宿主病口腔表征的临床及诊断分析  

The clinical and diagnosis analysis of chronic graft-versus-host disease in oral cavity.

作　　者：陶人川[1] 肖丽婷[1] 赖永榕[2] 

机构地区：[1]广西医科大学口腔医院牙周黏膜科,广西南宁530021 [2]广西医科大学第一附属医院血液科,广西南宁530021

出　　处：《临床口腔医学杂志》2011年第1期28-31,共4页Journal of Clinical Stomatology

基　　金：国家自然科学基金资助(30860313);广西回国人员科研基金资助(桂科回0639619)

摘　　要：目的:评价异基因造血干细胞移植后患者慢性移植物抗宿主病在口腔的临床表征及诊断,为移植物抗宿主病口腔表征患者的诊治提供依据。方法:计算机检索PubMed数据库(1966年～2010年3月),EMBASE(1989年～2010年3月),中国生物医学文献数据库(1980年～2010年3月)中英文文献。纳入慢性移植物抗宿主病中有口腔表征及诊断的研究文献,对纳入文献的口腔慢性移植物抗宿主病进行分析。结果:文献显示慢性移植物抗宿主病口腔表征的发病率较高,临床表现多样化。诊断标准不统一。结论:口腔溃疡,红斑病损,网状白斑病损是慢性移植物抗宿主病在口腔的常见表征,多数患者伴有疼痛,唾液分泌减少。在临床上应该对口腔慢性移植物抗宿主病有较全面的认识,同时其诊断标准尚待进一步规范。Objective：We performed a systematic review on patients who developed chronic graft-versus-host disease in oral cavity after allogeneic hematopoietic stem cell transplantation,and to offer evidence to the diagnosis an treatment for graft-versus-host disease in oral cavity.Method：Studies on oral chronic graft-versus-host disease in allogeneic hematopoietic stem cell transplantation were selected from a wider search based on five electronic databases：PubMed database（1966-March 2010）,EMBASE（1989-March 2010）,Chinese Biomedical Database（1980-March 2010）.No language restrictions were applied.According to our searching strategy and including criteria,35 studies were identified for analysis.Result：Literature shows that the oral chronic graft-versus-host disease has a higher prevalence and the oral manifestations were diverse.Diagnostic criteria is unclear yet.Conclusion：The commonest oral manifestation includes oral ulcers,erythema and lichen planus-like lesions among patients with chronic graft-versus-host disease.The majority of patients complained with pain and decreased salivary secretion.A better understanding on oral chronic graft-versus-host disease in clinical is needed in future,as wellas the diagnosis criteria needs to be modified further.

关 键 词：异基因造血干细胞移植 慢性移植物抗宿主病 口腔表征 

分 类 号：R781.5[医药卫生—口腔医学]