转化医学用于外源物所致宫内发育迟缓的临床早期诊断  

Use of translational medicine in the early diagnosis of xenobiotic-induced intrauterine growth retardation

作　　者：刘岩松[1] 汪晖[1] 

机构地区：[1]武汉大学基础医学院药理学系,湖北武汉430071

出　　处：《药学学报》2011年第1期30-34,2,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(30830112)

摘　　要：转化医学是一种医学研究理念,它强调打破以往研究组单一学科或有限合作的模式,加强基础研究人员与临床医生的密切合作,进而填平基础研究与临床医学之间的鸿沟。要达到转化医学的目标,需借助系统生物学的理论与方法。本文着重探讨如何运用转化医学的研究理念和系统生物学的研究方法,开展外源物所致宫内发育迟缓(IUGR)的临床早期诊断研究,包括提出IUGR发生的共性机制假说,利用系列组学(如基因组学、蛋白质组学、细胞组学、代谢组学)和分子生物学技术开展验证性研究,代谢组学方法探寻IUGR生物标志物,生物信息学及计算生物学方法构建IUGR预测模型等,以建立一种新的、无创性的、高敏感性的IUGR早期评价标准。Translational medicine is an emerging idea in current medical research area.Typically,for the purpose of bridging the gap between basic and clinical research,it not only emphasizes the urgency and necessity to break the traditional working formats,including single subject centered research team and limited cooperation among different scientific groups,but also highlights a more close and frequent interaction between basic scientist and clinician.In order to reach this goal,the theory and method of systems biology should be employed.This paper mainly focused on a central issue that how to carry out an investigation on early clinical diagnosis of xenobiotic-induced intrauterine growth retardation（IUGR） by using research concept of translational medicine and method of systems biology.Briefly,a hypothesis of common mechanism of IUGR was first proposed and subsequent validation was performed via integrating — omics（e.g.genomics,proteomics,cytomics,metabonomics/metabolomics） and molecular biology techniques.Metabonomics was further utilized to explore IUGR biomarker and establish preliminary forecasting model by bioinformatics and computational biology,which is available for early diagnosis of IUGR and make a complement to current evaluation criteria.

关 键 词：转化医学 系统生物学 宫内发育迟缓 组学技术 生物标志物 

分 类 号：R963[医药卫生—微生物与生化药学]