病理性近视患者血清高敏C反应蛋白水平的变化  

Change of serum high sensitive C-reactive protein level in patients with pathologic myopia

作　　者：王淑然[1] 王忠海[1] 叶俊杰[1] 龙琴[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院眼科,北京100730

出　　处：《中华实验眼科杂志》2011年第1期68-71,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（30600692、81070755）

摘　　要：背景病理性近视是常见的致盲性眼病之一，国内外近期研究提示病理性近视发病过程中有免疫反应的参与，而炎症反应是影响免疫状态的重要原因。目的探讨血清高敏C反应蛋白（hs—CRP）在病理性近视患者中的表达水平。方法病理性近视患者30例为病理性近视组，单纯性近视30例为单纯近视组，正常健康人30例为正常对照组。抽取所有受试者晨间空腹静脉血2ml，离心后取上清，采用自动生化分析仪进行免疫透射比浊法分析，检测血清hs—CRP。结果病理性近视组年龄19—48岁，平均（30±10）岁；等效球镜屈光度为（-6．00～-22．00）D。单纯性近视组年龄17～45岁，平均（32±8）岁；等效球镜屈光度为（～1．00—600）D。正常对照组年龄18～46岁，平均（32±9）岁；等效球镜屈光度为（-1．00～＋1．00）D。病理性近视组hs-CRP浓度为（3．68±1．15）mmol／L，与单纯性近视组的（1．99±0．68）mmol／L和正常对照组的（2．11±O．66）mmol／L相比，差异均有统计学意义（q=10．69，P〈0．01；q=9．91，P〈0．01）。病理性近视患者血清hs-CRP浓度与屈光度无明显相关性（R2=0．037，P〉0．05）。结论病理性近视患者可能存在hs—CRP参与的炎症反应，hs—CRP在病理性近视发生中的作用机制尚待进一步探讨。Background Pathologic myopia is one of the common blinding eye diseases. Recent research suggests that immune response participates in the pathogenesis of pathologic myopia, and inflammation is an important factor that influent immune status. Objective Present study was to observe the change of high sensitive C-reactive protein （hs-CRP） in serum in the patients with pathologic myopia and explore the role of inflammation in the development of pathologic myopia. Methods Serum hs-CRP was measured from 30 patients with pathologic myopia,30 patients with simple myopia and 30 normal controls with Nephelometric Turbidity in the OLYMPUS AU5400 automatic biochemical analyzer. Written informed consent was obtained from each subject before medical examination. Results The mean age was （30±10） years in pathologic myopia group,and （32±8） years in simple myopia group and （32±9） years in normal control group. The range of preoperative spherical equivalent refraction was （ -6. 00--22.00）D in pathologic myopia group, （ -1.00--6. 00）D in simple myopia group and （ -1.00±1.00）D in normal control group. The level of hs-CRP in serum was （3.68 ± 1. 15 ）mmol/L in the patients with pathologic myopia and was significantly higher than that of simple myopia group （1.99±0. 68 mmol/L） and normal controls （2.11±0.66 mmol/L） （ q = 10. 69, P〈0.01 ; q = 9.91, P〈0.01 ） , respectively. No significant correlation was found between hs-CRP level and myopic degrees in pathologic myopia group （ R2 = 0. 037, P 〉 0.05 ）. Conclusion Hs-CRP may play role in the inflammatory reaction during the pathogenesis of pathologic myopia.

关 键 词：病理性近视 高敏C反应蛋白 炎症 

分 类 号：R778.11[医药卫生—眼科]